Chronic Thromboembolic Pulmonary Hypertension: the Bench.

Current Cardiology Reports
George A AlbaSudarshan Rajagopal


Chronic thromboembolic pulmonary hypertension (CTEPH) is an uncommon complication of acute pulmonary embolism (PE), in which the red, platelet-rich thrombus does not resolve but forms into an organized yellow, fibrotic scar-like obstruction in the pulmonary vasculature. Here we review the pathobiology of CTEPH. Our current knowledge has predominantly been informed by studies of human samples and animal models that are inherently limited in their ability to recapitulate all aspects of the disease. These studies have identified alterations in platelet biology and inflammation in the formation of a scar-like thrombus that comprised endothelial cells, myofibroblasts, and immune cells, along with a small vessel pulmonary arterial hypertension-like vasculopathy. The development of CTEPH-specific therapies is currently hindered by a limited knowledge of its pathobiology. The development of new CTEPH medical therapies will require new insights into its pathobiology that bridge the gap from bench to bedside.


Jan 1, 1995·Chest·C A Wagenvoort
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·H KimuraT Kuriyama
Dec 24, 2003·Human Pathology·Lori A BlauwetChristopher G A McGregor
Jul 14, 2004·Chest·Frank LangerHans-Joachim Schäfers
Dec 27, 2005·Journal of Vascular Surgery·Matthew WalthamAlberto Smith
Jun 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Simone M FlightPatrick J Gaffney
Feb 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Diana BondermanIrene M Lang
Aug 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·B ModaraiA Smith
Sep 19, 2008·The European Respiratory Journal·D BondermanI M Lang
Apr 4, 2009·Journal of the American College of Cardiology·Rozenn QuarckMarion Delcroix
Apr 24, 2010·The European Respiratory Journal·D M SmadjaD Israël-Biet
Mar 17, 2011·International Journal of Cardiology·Miki MaruokaKoichiro Tatsumi
Jan 24, 2012·The European Respiratory Journal·Marijke WynantsMarion Delcroix
Nov 7, 2012·Pulmonary Circulation·Michael H Kroll, Vahid Afshar-Kharghan
Jan 15, 2013·The European Respiratory Journal·Olaf Mercier, Elie Fadel
Jul 26, 2013·The New England Journal of Medicine·Hossein-Ardeschir GhofraniUNKNOWN CHEST-1 Study Group
Sep 18, 2013·The Journal of Trauma and Acute Care Surgery·Jonathan B LundyTodd E Rasmussen
Oct 8, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Marijke WynantsRozenn Quarck
Jan 18, 2014·Cell and Tissue Research·Jamie R Privratsky, Peter J Newman
Jan 18, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Colin E EvansAlberto Smith
Mar 4, 2014·Journal of the American Heart Association·Maria K FreyIrene M Lang
Jun 22, 2014·Circulation Research·Marlene RabinovitchMark R Nicolls
Jul 10, 2014·Pulmonary Circulation·Olaf MercierElie Fadel
Jul 19, 2014·The European Respiratory Journal·Diana ZabiniAndrea Olschewski
Aug 16, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David BoulateOlaf Mercier
Aug 30, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Nobuhiro YaoitaHisanori Horiuchi
Jun 3, 2016·Pulmonary Circulation·Daniel T Matthews, Anna R Hemnes
Aug 30, 2016·Annals of the American Thoracic Society·Irene M LangAnton Vonk Noordegraaf

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