Chronic Thromboembolic Pulmonary Hypertension: Endovascular Treatment

Korean Circulation Journal
Chul Min Ahn, Matsubara Hiromi

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare cause of pulmonary hypertension; less than 5% of pulmonary hypertension is caused by recurrent pulmonary thromboembolism (PTE). By definition, CTEPH happens within the first two years after symptomatic PTE; however, cases are often diagnosed without a history of acute PTE. Because of the poor functional status and chronicity of this disease, the classic and curative strategy of open pulmonary endarterectomy cannot be applied in some patients with lesions that involve the distal subsegmental pulmonary artery. Bridging therapy is needed for cases that are technically operable but have an unacceptable risk-benefit assessment or residual symptomatic pulmonary hypertension following surgical removal. Groups in Europe and Japan recently introduced balloon pulmonary angioplasty or percutaneous transluminal pulmonary angioplasty, which has led to significant improvement in functional and hemodynamic parameters in patients with CTEPH. This article introduces recent updates in patient selection and interventional procedures for this chronic and devastating disease.

References

Oct 10, 2001·Clinics in Chest Medicine·P F FedulloL J Rubin
Jan 17, 2002·The New England Journal of Medicine·P F FedulloL J Rubin
Dec 22, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichiro SugimuraHiroaki Shimokawa
Jun 16, 2012·The European Respiratory Journal·Irene M LangJason X-J Yuan
Nov 8, 2012·Circulation. Cardiovascular Interventions·Masaharu KataokaToru Satoh
Nov 30, 2012·Circulation. Cardiovascular Interventions·Hiroki MizoguchiHiromi Matsubara
Jul 26, 2013·The New England Journal of Medicine·Hossein-Ardeschir GhofraniUNKNOWN CHEST-1 Study Group
Mar 31, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Joanna Pepke-ZabaMarius M Hoeper
Nov 5, 2017·Circulation. Cardiovascular Quality and Outcomes·Aiko OgawaHiromi Matsubara
Apr 20, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Aiko Ogawa, Hiromi Matsubara
May 26, 2018·Journal of the American College of Cardiology·Ehtisham MahmudWilliam R Auger

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Citations

Aug 10, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Rita CaléHélder Pereira

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Methods Mentioned

BETA
percutaneous transluminal pulmonary angioplasty
dissection

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