Chronic toxicity of a mixture of chlorinated alkanes and alkenes in ICR mice

Journal of Toxicology and Environmental Health. Part a
Fun-In WangTzuu-Huei Ueng

Abstract

The aim of this study was to determine the chronic toxicity of a mixture of chlorinated alkanes and alkenes (CA) consisting of chloroform, 1,1-dichloroethane, 1,1-dichloroethylene, 1,1,1-trichloroethane, trichloroethylene, and tetrachloroethylene. These chlorinated organic solvents were present in the underground water near an electronic appliances manufactory in Taoyuan, Taiwan. Male and female weanling ICR mice were treated with low-, medium-, and high-dose CA mixtures in drinking water for 16 and 18 mo, respectively. A significant number of male mice treated with the high-dose CA mixture developed tail alopecia and deformation, which was not prominent in CA-treated female mice. Medium- and high-dose CA mixtures induced marginal increases of liver and lung weights, blood urea nitrogen, and serum creatinine levels in male mice. In female mice, the high-dose CA mixture increased liver, kidney, and uterus and ovary total weights, without affecting serum biochemistry parameters. CA mixtures had no effects on the total glutathione content or the level of glutathione S-transferase activity in the livers and kid- neys of male and female mice. Treatments with CA mixtures produced a trend of increasing frequency of hepatocelluar neopl...Continue Reading

References

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Citations

Jan 12, 2010·The Science of the Total Environment·Lukas Jyuhn-Hsiarn LeeJung-Der Wang
Aug 30, 2008·Regulatory Toxicology and Pharmacology : RTP·Makoto SeoHisamitsu Nagase
Aug 30, 2014·Journal of Occupational Health·Enrico OddoneMarcello Imbriani
Oct 26, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·L Szatkowski, M B Hall
Apr 3, 2012·The Journal of Toxicological Sciences·Makoto SeoHisamitsu Nagase

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