PMID: 6537934Jan 1, 1984Paper

Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
W Lijinsky

Abstract

Methapyrilene hydrochloride was administered at levels of 125 or 250 ppm in the diet to groups of male and female F344 rats. The closely analogous antihistaminic drug pyrilamine, as the maleate, was given at 2000 ppm in the diet or at 2 g/litre drinking-water to groups of male and female F344 rats. Almost all of the rats given the higher dose of methapyrilene had either carcinomas or neoplastic nodules of the liver, whereas at 125 ppm 40% of the rats had neoplastic nodules in the liver. Among the 20 male and 20 female rats treated with pyrilamine maleate mixed into the diet, two males and two females had hepatocellular carcinomas and, in addition, five males and eight females had neoplastic nodules in the liver. The incidence of liver neoplasms in the rats given pyrilamine in the drinking-water did not differ from that in the untreated controls, of which five males and three females had neoplastic nodules in the liver.

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Citations

Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·W Lijinsky, R M Kovatch
Feb 18, 2011·Archives of Toxicology·Giovanni BrambillaAntonietta Martelli
Jun 1, 1991·Mutation Research·J Ashby
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Dec 1, 1990·Mutation Research·H S Rosenkranz, G Klopman
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May 16, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Costas KoufarisNigel J Gooderham
Oct 5, 2011·Mutation Research·Giovanni BrambillaAntonietta Martelli
Sep 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R C Kammerer, D A Schmitz
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Jul 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R C KammererK Kloc
Sep 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R C Kammerer, D A Schmitz
Jul 1, 1986·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R C Kammerer, D A Schmitz
Sep 20, 2005·Toxicology and Applied Pharmacology·M Firoze KhanJianling Wang
Nov 1, 2008·Ecotoxicology and Environmental Safety·Francesco Di GirolamoAngela Bachi
Oct 29, 2013·Journal of Proteome Research·Zsuzsanna AmentJulian L Griffin
Dec 7, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Christine Ruehl-FehlertMatthias Rinke
Jan 1, 1988·Environmental and Molecular Mutagenesis·W Lijinsky
Jan 1, 1988·Environmental and Molecular Mutagenesis·J AshbyF Ratpan
Aug 22, 2002·Toxicologic Pathology·Hisham K HamadehRichard S Paules

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