Chronic Toxoplasmosis Modulates the Induction of Contact Hypersensitivity by TNCB in Mouse Model

The Korean Journal of Parasitology
Zhaoshou YangHo-Woo Nam

Abstract

Mouse models of chronic toxoplasmosis and atopic dermatitis (AD) were combined to clarify the effect of opportunistic Toxoplasma gondii infection on the development of AD. AD was induced as a chronic contact hypersensitivity (CHS) with repeated challenge of 2,4,6-trinitro-1-chlorobenzene (TNCB) on the dorsal skin of mice. TNCB induced skin thickness increases in both normal and toxoplasmic mice. The changing patterns were different from the sigmoidal which saturated at 20 days in normal mice to the convex saturated at 12 days in toxoplasmic mice with the crossing at 18 days. Compared to normal mice, toxoplasmic mice presented CHS more severely in earlier times and then moderately in later times. These data suggest that host immune modification by T. gondii infection enhances CHS in early times of atopic stimulation but soothes the reaction of CHS in later times in mouse model.

References

Mar 23, 2000·The Journal of Experimental Medicine·H YokozekiK Nishioka
Apr 3, 2004·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Katsuo MatsumotoHachiro Tagami
Mar 1, 2005·Journal of Dermatological Science·Daisuke HaradaHaruhiko Manabe
Jun 3, 2009·The Korean Journal of Parasitology·Hye-Jin AhnHo-Woo Nam
Sep 7, 2011·Trends in Parasitology·Mariane B MeloJeroen P J Saeij
Oct 17, 2012·Nature Reviews. Microbiology·Christopher A Hunter, L David Sibley
Feb 20, 2014·PLoS Neglected Tropical Diseases·Vasco RodriguesJérôme Estaquier

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