Chronic treatment of pathological hyperprolactinemia and acromegaly with the new ergot derivative terguride

The Journal of Clinical Endocrinology and Metabolism
D DallabonzanaR Horowski

Abstract

The long term effectiveness and tolerance of terguride, a new ergot derivative, as initial therapy were evaluated in 20 patients with pathological hyperprolactinemia (PHP; group A) and 7 patients with acromegaly. We also studied 10 patients with PHP whose treatment was changed from bromocriptine or lisuride to terguride (group B). Terguride, given for at least 6 months in divided doses ranging from 0.25-1.50 mg/day to group A patients, resulted in normal (11 patients) or markedly reduced plasma PRL levels. Gonadal function was restored in all but 2 patients in this group, and the tumors shrank in 3 of 5 patients with a macroprolactinoma and in 1 of 3 patients with a microprolactinoma. In group B patients, positive effects of the previous treatment on PRL levels, gonadal function, and tumor growth were maintained by terguride. Terguride suppressed plasma GH levels below 50% of baseline in 4 of the 7 acromegalic patients. Two of the 27 patients initially treated with terguride complained of mild nausea and postural hypotension only after the first dose (0.25 mg) of the drug. No patient in group B had any side-effects during terguride, with the exception of 1 patient who was also intolerant to bromocriptine. We conclude that tergu...Continue Reading

Citations

Jan 1, 1990·European Journal of Clinical Pharmacology·W KrauseR Dorow
Mar 23, 2011·Nature Reviews. Endocrinology·Annamaria Colao, Silvia Savastano
Jul 13, 1999·Journal of Endocrinological Investigation·S CannavòF Trimarchi
Dec 4, 1990·Klinische Wochenschrift·G BenkerD Reinwein
Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Annamaria Colao
Aug 20, 2008·Clinical Endocrinology·Jana JezkováJosef Marek
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Apr 2, 1990·Klinische Wochenschrift·C WüsterR Ziegler
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