Chronic treatment with a precursor of cellular phosphatidylcholine ameliorates morphological and behavioral effects of aging in the mouse [correction of rat] hippocampus

Annals of the New York Academy of Sciences
D CrespoR Verduga

Abstract

Normal aging is commonly associated with a decline in memory, mainly for that related with newly acquired information. The hippocampal formation (HF) is a brain region that has been implicated in this dysfunction. Within the HF there are several cellular types, such as pyramidal cells, granule neurons of the dentate gyrus, and astrocytes. CDP-choline is a well-known intermediate in the biosynthesis of phosphatidylcholine, a phospholipid essential for neuronal membrane preservation and function; thus, this compound would attenuate the process of neuronal aging. To test this, three groups of male mice were used in this study. An adult 12-month-old group (ACG), a 24-month-old (OCG), and an old experimental group (OEG) were administered orally a solution of CDP-choline (150 mg/kg per day) from 12 up to 24 months. Experimental observations suggest that CDP-choline has a positive effect on memory (reference errors were attenuated), and hippocampal morphology resembled that of younger animals.

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Citations

Jul 7, 2007·The International Journal of Neuroscience·Khaled RadadWolf-Dieter Rausch
Jan 5, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Sarah KnippenbergSusanne Petri
Jun 16, 2015·Nutrition & Diabetes·K GoncharovaS G Pierzynowski
May 27, 2011·Journal of Pharmacological Sciences·Kotaro TakasakiKatsunori Iwasaki
May 15, 2016·Toxicology and Industrial Health·Ahmed O Abdel-ZaherDoaa H Abd El-Hamid
Feb 9, 2016·Critical Reviews in Food Science and Nutrition·Géraldine BouéJeanne-Marie Membré
Mar 23, 2018·Frontiers in Aging Neuroscience·Jeffery M ReddanAndrew Pipingas

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