Chronic treatment with angiotensin AT1 receptor antagonists reduced serum but not bone TGF-beta1 levels in ovariectomized rats

Canadian Journal of Physiology and Pharmacology
Yong-Qi LiQiu-Ju Huang

Abstract

Approximately 50% of hypertensive patients are postmenopausal women; therefore, any antihypertensive therapy must not adversely affect bone loss in this population. Recently, however, concern has been raised that use of angiotensin AT1 receptor antagonists may increase the tendency to develop postmenopausal osteoporosis by decreasing transforming growth factor-beta1 (TGF-beta1), which has been implicated in bone mass maintenance. In the present study, we selected telmisartan and valsartan as representatives of angiotensin AT1 receptor antagonists and used ovariectomized (OVX) rats as a model of human postmenopausal osteoporosis. After 3 months treatment with telmisartan (5 mg/kg daily) or valsartan (10 mg/kg daily), OVX rats showed no signs of adverse effects on bone mineral density of the lumbar vertebrae (L1-L5) or the total femur, nor did treatment affect serum levels of osteocalcin and osteoclast-derived tartrate-resistant acid phosphatase (TRACP-5b). Bone TGF-beta1 content remained unchanged, although treatment with telmisartan and valsartan significantly reduced serum TGF-beta1 levels (p < 0.05). In conclusion, chronic treatment with angiotensin AT1 receptor antagonists reduced serum but not bone TGF-beta1 levels and did ...Continue Reading

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Citations

Oct 1, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Walter Cristiano GealhRoberta Okamoto
May 9, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Debra A ButtUNKNOWN Hypertension Outcome, Surveillance Team
Oct 23, 2012·Pharmacological Reports : PR·Baris Ozgur DonmezNurettin Oguz
Sep 9, 2016·Pharmacological Reports : PR·Antonio Marcos BirocaleNazaré Souza Bissoli

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