Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Arquivos de neuro-psiquiatria
Hossein HaddadiSomayeh Shahidani

Abstract

The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients.

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Citations

Jul 13, 2019·Biomolecules·Michele CiullaAntonio Di Stefano
Aug 1, 2019·Neurotoxicity Research·Mahboubeh ManouchehrabadiAnahita Torkaman-Boutorabi
Dec 11, 2019·Biomolecules·Diogo Vilar da FonsêcaDamião Pergentino de Sousa
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Elena Todirascu-CiorneaAbdel Nasser B Singab
Oct 27, 2018·Neuroscience and Biobehavioral Reviews·Fanny FaivreMichel Barrot
Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Sandro PercárioMaria Fani Dolabela
May 11, 2021·CNS & Neurological Disorders Drug Targets·Mohammad Yassin ZamanianGholamreza Bazmandegan
Dec 15, 2021·The European Journal of Neuroscience·Kubra Celik TopkaraSerif Demir

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