Chronic treatment with dizocilpine maleate increases the number of striatal neurons expressing the D2 receptor gene

Neuroscience
B LannesG Micheletti

Abstract

N-methyl-D-aspartate antagonists have been proposed as potential therapeutic agents in different neurological diseases, including Parkinson's disease. The effects of gene expression of a chronic treatment with the non-competitive N-methyl-D-aspartate antagonist, dizocilpine maleate (0.8 mg/kg day, per os for 50 days) were analysed in rat striata. Using quantitative in situ hybridization, we measured the messenger RNA expression of the genes encoding D1, D2 dopamine receptors, N-methyl-D-aspartate receptor 1 subunit of N-methyl-D-aspartate receptor, preproenkephalin A and substance P. Chronic treatment with dizocilpine maleate induced a moderate but significant increase in messenger RNA of the N-methyl-D-aspartate receptor 1 subunit in the striatum and the adjacent cortex, suggesting an action of dizocilpine maleate in these two regions. This treatment did not induce any change in D1 receptor, preproenkephalin A or substance P messenger RNA content in the striatum, whereas D2 receptor messenger RNA was increased in the striatum of treated rats. Microscopic analysis revealed that it was the number of medium-sized neurons expressing D2 receptor messenger RNA that was significantly enhanced, while the mean amount of message per cel...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D J SurmeierS T Kitai
Jun 30, 1992·Biochemical and Biophysical Research Communications·H SugiharaS Nakanishi
Aug 1, 1992·Brain Research. Molecular Brain Research·G MichelettiJ Zwiller
Jan 1, 1991·Journal of Neural Transmission. General Section·K Kannari, R Markstein
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C Le MoineB Bloch
Sep 1, 1991·Archives of Neurology·J T Greenamyre, C F O'Brien
Sep 18, 1990·Neuroscience Letters·C Le MoineB Bloch
Mar 26, 1990·Neuroscience Letters·M Dragunow, R L Faull
Sep 8, 1990·The Journal of Comparative Neurology·H W Berendse, H J Groenewegen
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C Le MoineB Bloch
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jan 1, 1989·Journal of Neural Transmission·M Carlsson, A Carlsson
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Sep 30, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M Kemp, T P Powell
Jan 1, 1970·Brain : a Journal of Neurology·J M Kemp, T P Powell
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F TangJ P Schwartz
Jan 1, 1993·Journal of Neural Transmission. General Section·J T Greenamyre

❮ Previous
Next ❯

Citations

Jan 1, 1995·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·M S Starr
Mar 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M JessaA Plaznik
Mar 18, 2008·European Journal of Pharmacology·Gad KleinBenjamin Kest
Apr 8, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Camron D BryantChristopher J Evans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.