Chronic treatment with fluvoxamine, clovoxamine, and placebo: interaction with digoxin and effects on sleep and alertness

Journal of Clinical Pharmacology
H R OchsL Labedski

Abstract

The influence of 17 days of administration of fluvoxamine or clovoxamine, two new antidepressant agents, on the kinetics of a single intravenous dose of digoxin, and on self-rated parameters of sedation, mood, and sleep, was evaluated in a series of healthy volunteers. In the fluvoxamine study, subjects received fluvoxamine, 100 mg daily, or matching placebo for 17 consecutive days in a crossover design. For the clovoxamine study, subjects received clovoxamine, 150 mg daily, or placebo for 17 days. All treatments were double blind. At the end of each treatment, digoxin kinetics were evaluated following a single 1.25 mg intravenous dose. Compared to the placebo condition, fluvoxamine had no significant influence on digoxin elimination half-life (57 vs 47 hours), volume of distribution (10.5 vs 10.3 liters/kg), total clearance (2.4 vs 3.0 ml/min/kg), or 72 hour urinary excretion (33 vs 37 percent of the dose). Likewise clovoxamine did not alter digoxin elimination half-life (39 vs 40 hours), volume of distribution (10.7 vs 10.2 liters/kg), or total clearance 3.4 vs 3.4 ml/min/kg). 72 hour urinary excretion of digoxin was slightly increased by clovoxamine (41 vs 50 percent of the dose, P less than .05). Self-ratings indicated a se...Continue Reading

References

Jan 1, 1976·Annual Review of Medicine·D J GreenblattS Lofgren
Sep 1, 1978·Clinical Pharmacology and Therapeutics·R I ShaderM D Allen
Aug 1, 1975·Seminars in Arthritis and Rheumatism·S L Lee, P H CHase
May 1, 1977·The American Journal of Psychiatry·D J GreenblattJ Koch-Weser
Jan 1, 1985·Journal of Cardiovascular Pharmacology·H R OchsD J Greenblatt
Nov 1, 1985·Clinical Pharmacology and Therapeutics·H R OchsB Verburg-Ochs
Jan 1, 1987·Computers in Biology and Medicine·J S Harmatz, D J Greenblatt
May 1, 1986·Clinical Pharmacology and Therapeutics·R I ShaderD J Greenblatt
Sep 27, 1973·The New England Journal of Medicine·D J GreenblattT W Smith
Nov 27, 1969·The New England Journal of Medicine·T W SmithE Haber
Jan 1, 1984·European Journal of Clinical Pharmacology·H R OchsB Verburg-Ochs
Jan 1, 1984·Annual Review of Medicine·A H Glassman
Apr 1, 1983·Clinical Pharmacology and Therapeutics·H R OchsR I Shader
Jan 1, 1983·European Journal of Clinical Pharmacology·P DorianT Fan
Jan 1, 1980·Folia Psychiatrica Et Neurologica Japonica·S WatanabeC Kuyama
Jul 1, 1981·Archives of General Psychiatry·A H Glassman, J T Bigger
Sep 1, 1980·Clinical Pharmacology and Therapeutics·H R OchsG Bodem

❮ Previous
Next ❯

Citations

Dec 21, 2004·British Journal of Clinical Pharmacology·David N JuurlinkAndreas Laupacis
Mar 3, 2015·Expert Opinion on Drug Metabolism & Toxicology·Alfredo Carlo AltamuraMassimiliano Buoli
Sep 10, 2015·Drug Metabolism and Personalized Therapy·Eric L SingmanVirginia Pearson
Dec 5, 2006·Lancet·Pär Hallberg, Håkan Melhus
Apr 22, 2005·British Journal of Clinical Pharmacology·G J H DumontUNKNOWN Biomarker Working Group of the German Association for Applied Human Pharmacology
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Johanna WeissWalter Emil Haefeli
Oct 19, 2001·CNS Drug Reviews·H Silver
Apr 9, 2005·The Clinical Journal of Pain·Katherine Harman, Peggy Ruyak
Sep 1, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Toshiro NiwaAkira Takagi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.