Chronic treatment with ginsenoside Rg1 promotes memory and hippocampal long-term potentiation in middle-aged mice

Neuroscience
G ZhuJ Wang

Abstract

Ginseng serves as a potential candidate for the treatment of aging-related memory decline or memory loss. However, the related mechanism is not fully understood. In this study, we applied an intraperitoneal injection of ginsenoside Rg1, an active compound from ginseng in middle-aged mice and detected memory improvement and the underlying mechanisms. Our results showed that a period of 30-day administration of ginsenoside Rg1 enhanced long-term memory in the middle-aged animals. Consistent with the memory improvement, ginsenoside Rg1 administration facilitated weak theta-burst stimulation (TBS)-induced long-term potentiation (LTP) in acute hippocampal slices from middle-aged animals. Ginsenoside Rg1 administration increased the dendritic apical spine numbers and area in the CA1 region. In addition, ginsenoside Rg1 administration up-regulated the expression of hippocampal p-AKT, brain-derived neurotrophic factor (BDNF), proBDNF and glutamate receptor 1 (GluR1), but not p-ERK. Interestingly, the phosphatase and tensin homolog deleted on chromosome ten (PTEN) inhibitor (bpV) mimicked the ginsenoside Rg1 effects, including increasing p-AKT expression, promoting hippocampal basal synaptic transmission, LTP and memory. Taken together,...Continue Reading

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Citations

Jun 9, 2016·Journal of Exercise Nutrition & Biochemistry·Saebom Haam, Hyon Park
Mar 10, 2016·European Journal of Pharmacology·Yuan-Lin WangXin Chen
Jun 9, 2016·BioMed Research International·Fengling LiKexiang Wu
Dec 3, 2016·European Journal of Pharmacology·Junyao LiGuoqi Zhu
Feb 22, 2018·Neural Plasticity·Enrico SangiovanniFrancesca Calabrese
May 23, 2017·Journal of Oral Science·Xiaofeng DuanYufeng Song
Jul 22, 2017·Molecular Medicine Reports·Jing-Yun ZhangQiu-Mei Zhang
Apr 9, 2020·Frontiers in Cellular Neuroscience·Wei HouRanji Cui
Jan 29, 2019·Neural Regeneration Research·Zhu-Jin SongGuoqi Zhu
Nov 16, 2020·Journal of Ethnopharmacology·Mengjiao HeChunchao Han
Jul 24, 2021·Journal of Ginseng Research·Feiyan ChenYunan Zhao

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