PMID: 19928186Nov 26, 2009Paper

Chronic treatment with nanoparticles exacerbate hyperthermia induced blood-brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired-antioxidant compound H-290/51

Journal of Nanoscience and Nanotechnology
Hari Shanker SharmaDafin F Muresanu

Abstract

The possibility that chronic exposure of nanoparticles may alter stress reaction and brain pathology following hyperthermia was examined in a rat model. Engineered nanoparticles from Ag or Cu (approximately equal to 50-60 nm) were administered (30 mg/kg, i.p.) once daily for 1 week in young male rats. On the 8th day these animals were subjected to 4 h heat stress at 38 degrees C in a BOD incubator. In these animals stress symptoms, blood-brain barrier (BBB) permeability, cognitive and motor functions and brain pathology were examined. Subjection of nanoparticle treated rats to heat stress showed exacerbation of stress symptoms i.e., hyperthermia, salivation and prostration and exhibited greater BBB disruption, brain edema formation, impairment of cognitive and motor functions and brain damage compared to normal animals. This enhanced brain pathology in heat stress was most marked in animals that received Ag nanoparticles compared to Cu treatment. Treatment with antioxidant compound H-290/51 either 30 min or 60 min after heat stress did not alter hyperthermia induce brain pathology in nanoparticle treated rats. Whereas, administration of nanowired-H-290/51 after 30 min or 60 min heat stress markedly attenuated BBB disruption, se...Continue Reading

Citations

Aug 18, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·William J TricklerSyed F Ali
Dec 4, 2012·International Journal of Molecular Sciences·Ting WangXiaojun Zhao
Feb 22, 2012·Nanomedicine·William J TricklerSyed F Ali
Dec 30, 2014·Archives of Toxicology·Carmen GonzalezSyed F Ali
Oct 15, 2014·Expert Opinion on Drug Metabolism & Toxicology·Hari S SharmaAruna Sharma
Mar 29, 2014·Journal of Food and Drug Analysis·Alokita KarmakarYongbin Zhang
Nov 14, 2012·Ecotoxicology and Environmental Safety·Peidang LiuNing Gu
Apr 10, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Robert YokelRobert MacPhail
Oct 22, 2016·Advanced Pharmaceutical Bulletin·Shringika SoniBikash Medhi
Jun 27, 2018·Journal of Applied Toxicology : JAT·Lucía Z Flores-LópezRatnasamy Somanathan
Mar 22, 2014·Chemical Society Reviews·Yi ZhangBing Yan
Jul 21, 2020·Journal of Applied Toxicology : JAT·Xiaoru ChangMeng Tang
Mar 20, 2015·The Journal of Toxicological Sciences·Shahab GhaderiMasome Rashno
Sep 20, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Phoebe A StapletonTimothy R Nurkiewicz
Jun 8, 2017·Scientific Reports·Angela B JavurekCheryl S Rosenfeld
May 29, 2020·IET Nanobiotechnology·Somya Ranjan Dash, Chanakya Nath Kundu
Feb 7, 2021·Toxics·Anna A AntsiferovaMikhail V Kovalchuk
Jun 15, 2021·Frontiers in Pharmacology·Feng-Dan ZhuAn-Guo Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

© 2022 Meta ULC. All rights reserved