Chronic treatment with propranolol induces antioxidant changes and protects against ischemia-reperfusion injury

Journal of Molecular and Cellular Cardiology
N KhaperP K Singal

Abstract

The goal of this study was to examine whether chronic administration of propranolol offers protection against ischemia-reperfusion injury and whether it induces any change in the myocardial endogenous antioxidant enzyme activities and their gene expression. Rats were treated with propranolol (10 mg/kg/day, i.p.) for either 6 or 18 days. Forty-eight h after the last propranolol injection, isolated hearts were subjected to 60 min of global ischemia and 40 min of reperfusion. Resting tension in the control and treated groups after ischemia was 385+/-30 and 150+/-15%; and upon reperfusion was 140+/-11 and 49+/-6%, respectively, as compared to the pre-ischemic values. Recovery of the contractile function in globally ischemic hearts upon reperfusion was about 35% in the treated group as compared to about 16% in the control group at 10 and 20 min. A positive response to catecholamine was observed in hearts from propranolol group (C, 3.41+/-0.36; epi, 6.03+/-0.47 g/g) and was comparable to control hearts (C, 3.55+/-0.31; epi, 6.48+/-0.42 g/g). Myocardial antioxidants, catalase and glutathione peroxidase enzyme activities, in the treated group, prior to ischemia-reperfusion were increased by 67+/-9 and 45+/-11%, respectively, over those...Continue Reading

Citations

May 8, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Saori KurosawaAkiyoshi Namiki
Apr 13, 2010·Antioxidants & Redox Signaling·Neelam KhaperPawan K Singal
Jun 29, 2000·Journal of Hypertension·N S DhallaT Netticadan
May 17, 2006·Clinical and Experimental Pharmacology & Physiology·Fernanda B M PrivieroEdson Antunes
Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Benjamin F DickensTong I Mak
Jul 7, 2007·Canadian Journal of Physiology and Pharmacology·Dinender K SinglaPawan K Singal
Aug 2, 2003·Biotechnology Progress·Qin Meng
Jun 19, 2009·Expert Opinion on Therapeutic Targets·Ioanna AndreadouDimitrios Th Kremastinos
Jul 25, 2012·Progress in Cardiovascular Diseases·Jawwad YusufKarl T Weber
Mar 21, 2007·Journal of Cellular and Molecular Medicine·Margherita NeriVittorio Fineschi
Mar 3, 2006·Bioorganic & Medicinal Chemistry·Ana GomesEduarda Fernandes
Oct 30, 2004·Scandinavian Cardiovascular Journal : SCJ·Yoshihiro SuematsuPedro del Nido
May 31, 2014·European Journal of Pharmacology·Anna RapaczHenryk Marona
Jul 5, 2016·European Journal of Pharmacology·Louise E See HoeJason N Peart
Dec 26, 2001·Hypertension·A López Farré, S Casado
Oct 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·I Tong Mak, William B Weglicki

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