PMID: 7088256Mar 1, 1982Paper

Chronic triethyltin exposure reduces the resting membrane potential of rat soleus muscle

Neurobehavioral Toxicology and Teratology
W R Millington, G G Bierkamper


Muscle weakness is a prominent component of the toxic syndrome which results from prolonged exposure to triethyltin (TET). The etiology of this phenomenon includes, in part, an alteration of acetylcholine (ACh) release from motoneurons but there are also indications that TET causes a primary myopathy. We have found that chronic exposure of rats to TET bromide (30 mg/liter of drinking water) caused a time-dependent reduction of resting membrane potentials (RMPs) recorded in situ from soleus muscle fibers. The RMPs of TET-exposed rats were significantly lower than those of control animals (5.4 mV) after four days and were further reduced by continuous TET exposure to 11.2 mV less than control on the twenty-eighth day. Three weeks after rats were withdrawn from TET RMPs were restored to control values. TeT had no effect on the frequency, amplitude or incidence of occurrence of miniature endplate potentials. Spontaneous ACh release ane its action on the postsynaptic membrane were not affected by TET, which suggests that TET reduces RMPs through an effect on muscle fibers unrelated to denervation. We propose that TET reduces RMPs by inhibiting the bioenergetic capacity of the muscle and that this myogenic toxicity is a significant f...Continue Reading

Related Concepts

Energy Metabolism
Resting Potentials
August Rats
Trialkyltin Compounds
Triethyltin Compounds

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.