Chronic umbilical cord compression results in accelerated maturation of lung and brown adipose tissue in the sheep fetus during late gestation

American Journal of Physiology. Endocrinology and Metabolism
Muhuntha G GnanalinghamD S Gardner

Abstract

Umbilical cord compression (UCC) sufficient to reduce umbilical blood flow by 30% for 3 days, results in increased fetal plasma cortisol and catecholamines that are likely to promote maturation of the fetal lung and brown adipose tissue (BAT). We determined the effect of UCC on the abundance of uncoupling protein (UCP)1 (BAT only) and -2, glucocorticoid receptor (GR), and 11beta-hydroxysteroid dehydrogenase (11beta-HSD)1 and -2 mRNA, and mitochondrial protein voltage-dependent anion channel (VDAC) and cytochrome c in these tissues. At 118 +/- 2 days of gestation (dGA; term approximately 145 days), 14 fetuses were chronically instrumented. Eight fetuses were then subjected to 3 days of UCC from 125 dGA, and the remaining fetuses were sham operated. All fetuses were then exposed to two 1-h episodes of hypoxemia at 130 +/- 1 and 134 +/- 1 dGA before tissue sampling at 137 +/- 2 dGA. In both tissues, UCC upregulated UCP2 and GR mRNA, plus VDAC and cytochrome c mitochondrial proteins. In lung, UCC increased 11beta-HSD1 mRNA but decreased 11beta-HSD2 mRNA abundance, a pattern reversed for BAT. UCC increased UCP1 mRNA and its translated protein in BAT. UCP2, GR, 11beta-HSD1 and -2 mRNA, plus VDAC and cytochrome c protein abundance wer...Continue Reading

References

Feb 21, 2006·Antioxidants & Redox Signaling·Gustav Mattiasson, Patrick G Sullivan
Aug 11, 2005·American Journal of Physiology. Endocrinology and Metabolism·Muhuntha G GnanalinghamTerence Stephenson
Aug 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michele K Wu, David E Cohen
Nov 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Srinivas NammiB L Grégoire Nyomba
Feb 22, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dean A MyersCharles A Ducsay
Jan 24, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Amanda N Sferruzzi-PerriA L Fowden
Jun 17, 2015·Annual Review of Nutrition·M E SymondsH Budge

Citations

Oct 1, 1978·Australian Journal of Biological Sciences·R T Gemmell, G Alexander
Mar 1, 1975·British Journal of Obstetrics and Gynaecology·T Wheeler, K Greene
Apr 1, 1989·American Journal of Obstetrics and Gynecology·J ChallisA D Bocking
Jul 1, 1986·American Journal of Obstetrics and Gynecology·L I Mann
Jan 1, 1966·British Medical Bulletin·R S Comline, M Silver
Nov 1, 1984·American Journal of Obstetrics and Gynecology·K J LevenoR T DePalma
Mar 1, 1994·American Journal of Obstetrics and Gynecology·R GagnonL Fraher
Jan 1, 1996·The American Journal of Physiology·M J WallaceR Harding
Mar 1, 1996·The Proceedings of the Nutrition Society·M E Symonds, L Clarke
Jan 1, 1997·Clinical Science·J B Prins, S O'Rahilly
Jun 1, 1997·The American Journal of Physiology·L ClarkeM E Symonds
Oct 24, 1997·In Vitro Cellular & Developmental Biology. Animal·L K RyanM W Vermeulen
Jun 20, 1998·The Journal of Physiology·A L FowdenM Silver
May 8, 1998·The Proceedings of the Nutrition Society·A L FowdenA J Forhead
Jun 25, 1998·American Journal of Respiratory Cell and Molecular Biology·J C SchittnyP H Burri
Jan 28, 1999·American Journal of Respiratory Cell and Molecular Biology·M C BruceR J Cross
Nov 11, 1999·Journal of the Society for Gynecologic Investigation·J F ClappS Simonean
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·D W VoehringerL A Herzenberg
Sep 27, 2000·Biochimica Et Biophysica Acta·K D GarlidM Varecha
Oct 6, 2000·FEBS Letters·R A Gottlieb
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B BuemannA Astrup
Jul 27, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·B R Walker
Feb 6, 2002·Chembiochem : a European Journal of Chemical Biology·B LudwigB Kadenbach
May 29, 2002·Diabetologia·A GrosfeldT Issad
Jun 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Takako KizakiHideki Ohno
Jan 15, 2003·The Journal of Endocrinology·A MostynM E Symonds
Jan 18, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Daliao XiaoLubo Zhang

Related Concepts

Brown Fat
Fetal Structures
Fetal Lung
Hibernating Gland
11-beta-Hydroxysteroid Dehydrogenases
Dioxygen
Salicylhydroxamic acid
Entire Fetus
AT 130
Lung

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