Chronic Urotensin-II Administration Improves Whole-Body Glucose Tolerance in High-Fat Diet-Fed Mice

Frontiers in Endocrinology
Xi ChenGuan-Hua Du

Abstract

Urotensin-II (U-II) is an endogenous peptide agonist of a G protein-coupled receptor-urotensin receptor. There are many conflicting findings about the effects of U-II on blood glucose. This study aims to explore the effects of U-II on glucose metabolism in high-fat diet-fed mice. Male C57BL/6J mice were fed a 45% high-fat diet or chow diet and were administered U-II intraperitoneally for in vivo study. Skeletal muscle C2C12 cells were used to determine the effects of U-II on glucose and fatty acid metabolism as well as mitochondrial respiratory function. In this study, we found that chronic U-II administration (more than 7 days) ameliorated glucose tolerance in high-fat diet-fed mice. In addition, chronic U-II administration reduced the weight gain and the adipose tissue weight, including visceral, subcutaneous, and brown adipose tissue, without a significant change in blood lipid levels. These were accompanied by the increased mRNA expression of the mitochondrial thermogenesis gene Ucp3 in skeletal muscle. Furthermore, in vitro treatment with U-II directly enhanced glucose and free fatty acid consumption in C2C12 cells with increased aerobic respiration. Taken together, chronic U-II stimulation leads to improvement on glucose ...Continue Reading

References

Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y CoulouarnH Vaudry
Feb 24, 2001·Exercise and Sport Sciences Reviews·J F Horowitz
Jul 18, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R A SilvestreJ Marco
Dec 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Hans J WoerleJohn E Gerich
Jun 18, 2003·The Journal of Cell Biology·Morris J Birnbaum
Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·Döne OnanWalter G Thomas
Sep 15, 2005·Psychopharmacology·Jean-Claude Do-RegoJean Costentin
Nov 4, 2005·The Journal of Pharmacology and Experimental Therapeutics·Martine ClozelMarkus Rey
Jan 5, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Véronic BézaireMary-Ellen Harper
May 6, 2008·Nature·Kirsty L SpaldingPeter Arner
May 9, 2008·International Journal of Biological Sciences·Zhihua JiangNancy S Magnuson
Mar 28, 2009·Regulatory Peptides·Hong Xia WangChao Shu Tang
Jun 23, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhipeng YouAdel Giaid Schwertani
Dec 4, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhipeng YouAdel Schwertani
May 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Guifen QiangGuanhua Du
Jul 20, 2016·World Journal of Gastroenterology : WJG·Ying-Ying LiXue-Jiang Wang
May 4, 2017·Cell Metabolism·Bret H Goodpaster, Lauren M Sparks
Jul 8, 2017·Experimental & Molecular Medicine·No-Joon SongKye Won Park
Mar 15, 2018·European Journal of Endocrinology·Miikka-Juhani HonkaPirjo Nuutila
May 17, 2018·Physiological Reviews·Sofiya GanchevaMichael Roden
Nov 25, 2018·Hormones : International Journal of Endocrinology and Metabolism·Mehmet CalanFırat Bayraktar

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Citations

Mar 13, 2021·General and Comparative Endocrinology·Pengxin JiangWeiqun Lu

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

GraphPad

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