PMID: 2492568Feb 1, 1989Paper

Chronic urticaria and macroglobulinemia (Schnitzler's syndrome): report of two cases

Journal of the American Academy of Dermatology
M JanierJ Civatte

Abstract

Two cases of chronic urticaria associated with macroglobulinemia are reported, and the characteristics of 13 other cases are reviewed. This entity was described by Schnitzler in 1974 and has the following characteristics: chronic nonpruritic urticaria with leukocytoclastic vasculitis, bone pains with hyperostosis, intermittent fever, and a monoclonal IgM gammopathy. Liver, lymph node, and spleen enlargement may occur. Criteria for the diagnosis of Waldenström's disease are lacking (IgM level less than 10 gm/L, no overt lymphoid proliferation in bone marrow). Other immunologic findings (complement, C1 inhibitor, cryoglobulin, rheumatoid factor, antinuclear antibodies) are negative or normal. Evolution is long-term with a long follow-up period. In one case a lymphoplasmocytic lymphoma developed. No adequate treatment has yet been found. Pathogenesis is unclear but seems to be caused by skin deposits of the IgM paraprotein, as attested to by the direct cutaneous immunofluorescent findings in some cases.

References

Jun 1, 1978·Archives of Dermatology·S O'LoughlinR E Jordon
Mar 1, 1974·Archives of Internal Medicine·J B ShumakerK J Isselbacher
Jun 1, 1983·The British Journal of Dermatology·R R JonesJ Schifferli
Nov 1, 1982·Journal of the American Academy of Dermatology·N P SanchezC H Dicken
Dec 1, 1982·Clinical Immunology and Immunopathology·J P ClauvelM Seligmann
Jul 1, 1981·Journal of the American Academy of Dermatology·E W Monroe

❮ Previous
Next ❯

Citations

Feb 1, 1994·Journal of the American Academy of Dermatology·C LebbeP Morel
Apr 14, 2000·La Revue de médecine interne·P GermainM Longy-Boursier
Dec 11, 1999·Clinics in Dermatology·A K Black
Jun 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·E N Charlesworth
Mar 22, 2000·Allergy·N Novak, T Bieber
May 16, 2000·The British Journal of Dermatology·D LipskerE Grosshans
Aug 28, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·F AlmerigognaS Romagnani
Aug 28, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·M Pascual-LópezA García-Díez
Sep 1, 1999·Pediatric Dermatology·H C NousariB A Cohen
Apr 28, 1999·The American Journal of Dermatopathology·P AppenzellerC T Thompson
Nov 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·D GazitM Ulmansky
Dec 15, 2010·Orphanet Journal of Rare Diseases·Dan Lipsker
Jul 11, 2013·Case Reports in Medicine·Gabriel TinocoDeepthi Moola
Jun 26, 2007·Seminars in Arthritis and Rheumatism·Heleen D de KoningUNKNOWN Schnitzler Syndrome Study Group
Apr 1, 1991·The Journal of Allergy and Clinical Immunology·S S Berdy, K J Bloch
Sep 12, 2006·International Journal of Dermatology·Martha KarakelidesCatherine R Weiler
Jul 1, 1990·The British Journal of Dermatology·L BorradoriP Morel
Sep 1, 1995·European Journal of Haematology·K Krishnan, P T Adams
May 4, 2004·Immunology and Allergy Clinics of North America·Mark D P Davis, Jerry D Brewer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Allergy and Clinical Immunology
S S Berdy, K J Bloch
Dermatology : International Journal for Clinical and Investigative Dermatology
F R de CastroJ-H Saurat
Journal of the American Academy of Dermatology
R M PujolJ M de Moragas
International Journal of Cancer. Journal International Du Cancer
Y SugimotoT Tsuruo
© 2022 Meta ULC. All rights reserved