Chronic urticaria due to autoreactivity to progesterone

Clinical and Experimental Dermatology
L Wingate-SaulM W Greaves

Abstract

A 23-year-old, regularly menstruating woman presented with recurrent urticarial eruptions, which occurred premenstrually. A skin prick test was positive for progesterone, but the urticaria was unresponsive to standard treatments. The patient was treated with goserelin (Zoladex), which suppressed her menstrual cycle, leading to the resolution of her symptoms. Subsequent flares were controlled by further goserelin injections, and the urticaria is currently in remission. However, the risks of inducing menopause artificially are significant, and alternative long-term solutions may need to be considered in the event of a relapse.

References

Feb 1, 1995·Journal of the American Academy of Dermatology·A J HerzbergV A Cirillo-Hyland
Nov 1, 1995·The British Journal of Dermatology·S M WilkinsonT P Kingston
May 31, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Joy L Snyder, Guha Krishnaswamy
Nov 2, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Frédéric DedeckerVéronique Salmon-Ehr

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Citations

Nov 12, 2015·Autoimmunity Reviews·Tegan Nguyen, A Razzaque Ahmed
Mar 24, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·E AmslerA Gompel
Jan 16, 2018·Journal of Cutaneous Medicine and Surgery·Aradhana SoodDeep Kumar Raman
Jan 20, 2018·Current Allergy and Asthma Reports·Rung-Chi LiJonathan A Bernstein
Oct 22, 2016·Journal of Cutaneous Pathology·Travis JamesAnn LaFond

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