Chronic Use of Statins and Their Effect on Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Frontiers in Pharmacology
Mahmud MahamidEran Goldin

Abstract

Background and Aims: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is one of the major complications of ERCP. Thus, several non-invasive as well as invasive strategies have been investigated as preventative therapies for PEP with various efficacy. Methods: We enrolled any patients who underwent ERCP both at the Shaare Zedek Medical Center in Jerusalem and EMMS Nazareth hospital. Association between use of statins and different variables were assessed with univariate tests (chi-squared for categorical variables). Predictors of incidence of PEP and severity of pancreatitis were computed using conditional logistic regression, correcting for potential confounding factors. Results: 958 subjects were analyzed. Average age was 62.04 ± 21.18 years (median 68 years). Most of the patients were female (n = 558, 58.2%), Jewish (n = 827, 86.3%), and inpatients (n = 631, 65.9%). Only few ERCPs were performed emergently (n = 40, 4.2%). Twenty-Seven patients repeated the exam. Overall incidence of PEP/hyperamylasemia was 16.8% (n = 161); with a 5.6% (n = 54) incidence of hyperamylasemia and a 11.2% (n = 107) incidence of pancreatitis. Overall, 6 cases of severe pancreatitis were identified. The logistic regressi...Continue Reading

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Citations

May 29, 2020·Expert Review of Gastroenterology & Hepatology·Antonio FacciorussoRodolfo Sacco
Jul 28, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Karina Cárdenas-JaénEnrique de-Madaria
Apr 25, 2020·BMC Gastroenterology·Yousaf Bashir HadiJohn Nasr
Jan 3, 2020·Journal of Clinical Gastroenterology·Ryunosuke HakutaKazuhiko Koike

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