PMID: 6412156Oct 1, 1983Paper

Chronic valproate administration reduces fasting ketonemia in children

Neurology
J H ThurstonV Tasch

Abstract

We previously found that chronic administration of sodium valproate to suckling infant mice reduced plasma beta-hydroxybutyrate levels but had no effect on plasma free fatty acid or glycerol concentrations. We now report that valproate has a similar effect in children taking the drug for epilepsy. In larger doses, valproate also depleted the infant mouse liver glycogen content. These findings may relate to the hepatic toxicity of valproate. We advise caution if the drug is being considered for use in chronically malnourished children or when the caloric intake of normal children is likely to be reduced during periods of acute illness.

Citations

Apr 9, 2008·Journal of Inherited Metabolic Disease·M F B SilvaI Tavares de Almeida
Jan 1, 1990·Biochemical Pharmacology·I RozasS Rodriguez-Segade
Jan 1, 1995·Pharmacology & Therapeutics·B Fromenty, D Pessayre
May 19, 2001·Neurologic Clinics·J W WhelessC Ghanbari
Jul 22, 1998·Epilepsia·K Ballaban-GilS Shinnar
Aug 22, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·F EbbesenM Rix
Apr 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·D M TurnbullK G Alberti
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·D C Lehotay, J T Clarke
Apr 1, 1990·Current Problems in Pediatrics·R R Clancy
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G R GrannemanJ M Machinist
Sep 1, 1986·Epilepsia·M C LaubG Jaeger
Jan 11, 1992·The Annals of Pharmacotherapy·E A BellB W Shaw
Jun 15, 1985·Biochemical Pharmacology·C Van den Branden, F Roels

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.