Chronic valproate fails to prevent imipramine-induced behavioural sensitization to the dopamine D2-like receptor agonist quinpirole

European Journal of Pharmacology
Paolo S D'AquilaGino Serra

Abstract

Based on experimental evidence suggesting a relationship between dopamine and mania, we proposed the antidepressant-induced dopaminergic supersensitivity as a model of antidepressant-related mania. We have previously shown the ability of carbamazepine, but not lithium, to prevent this phenomenon. Here we show that sodium valproate (50 mg/kg/day for 3 weeks) fails to prevent imipramine (20 mg/kg/day for 3 weeks)-induced sensitization to the locomotor response to the dopamine D2-like receptor agonist quinpirole (0.15 mg/kg). Since lithium, carbamazepine and valproate are all considered poorly effective in the treatment of antidepressant-related mania, the validity of the proposed model should be disproved by the carbamazepine results, to which, however, a pharmacokinetic mechanism might have concurred.

References

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Citations

Nov 8, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ajaykumar N SharmaJoao Quevedo
Feb 11, 2015·European Journal of Pharmacology·Francesca DemontisGino Serra
Nov 21, 2012·The International Journal of Neuropsychopharmacology·Jordy van EnkhuizenJared W Young
Dec 30, 2014·World Journal of Psychiatry·Giulia SerraGino Serra
Dec 5, 2009·Acta Psychiatrica Scandinavica·L TondoR J Baldessarini

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