Chronic Venous Disorders: The Dangerous, the Good, and the Diverse

International Journal of Molecular Sciences
Daniela LigiF Mannello

Abstract

Chronic venous disorders are common vascular pathology of great medical and socioeconomic impact, characterized by a wide spectrum of clinical manifestations occurring with symptoms and/or signs that vary in type and severity. The predominant pathophysiological mechanisms of chronic venous disease start from the development of venous hypertension from shear stress and reflux, leading to endothelial dysfunction and venous wall dilatation. The altered hemodynamic transduces physical signals into harmful bio-molecular pathways, creating a vicious cycle among shear stress, proteolytic remodeling, and inflammatory processes. This intricate network is further exacerbated by the degradation of protective endothelial glycocalyx. In this special issue, at least three main aspects of these interactions are highlighted: the dangerous, the good, and the diverse, which may help to focus attention on the biomolecular mechanisms and the possible targeted therapy of chronic venous disorders (CVeD).

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Citations

Sep 3, 2020·Vascular Medicine·Jiri Kanta, Anna Zavadakova
Apr 30, 2020·Journal of Clinical Medicine·Daniel P ZalewskiAnna Bogucka-Kocka
Sep 23, 2020·Cardiovascular Engineering and Technology·Sheldon WeinbaumJohn M Tarbell
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcin FeldoAnna Bogucka-Kocka
May 3, 2020·International Journal of Molecular Sciences·Marina M ZiganshinaGennady T Sukhikh
Jan 14, 2021·Journal of Wound Care·Francois SterpioneYann Lecomte
Dec 31, 2020·Journal of Clinical Medicine·Joseph D RaffettoFerdinando Mannello
Jan 1, 2021·BioMed Research International·Miguel A OrtegaFelipe Sainz

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Methods Mentioned

BETA
chemical modification

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