PMID: 6167806Jul 1, 1981Paper

Chronic ventricular tachyarrhythmias in the conscious dog: prevention by UM-272 (dimethylpropranolol)

Journal of Cardiovascular Pharmacology
E Patterson, B R Lucchesi

Abstract

The ability of chronic UM-272 (dimethylpropranolol) treatment to prevent the induction of reentrant ventricular tachyarrhythmias was assessed in the conscious dog subjected to serial programmed electrical stimulation on days 3--5 after myocardial infarction. In 20 untreated control animals, programmed electrical stimulation produced nonsustained ventricular tachycardia in 6 animals (30%), sustained ventricular tachycardia in 8 animals (40%), and ventricular fibrillation in 6 animals (30%) on the third day after occlusion and reperfusion of the left anterior descending coronary artery. On day 4, programmed electrical stimulation produced nonsustained ventricular tachycardia in 5 animals (36%), sustained ventricular tachycardia in 7 animals (50%), and ventricular fibrillation in 2 animals (14%). UM-272, 5 or 10 mg/kg, i.v., was administered every 12 hr to a separate group of 8 dogs after the induction of ischemic myocardial injury. Programmed electrical stimulation on day 3 after myocardial infarction failed to elicit ventricular arrhythmias in 4 animals (50%, p = 0.014), with acute administration of the next UM-272 dose preventing the induction of ventricular tachyarrhythmias in 7 animals (88%, p less than 0.0001). On day 4, pro...Continue Reading

Citations

Mar 4, 1983·European Journal of Pharmacology·B T EllerB R Lucchesi
Oct 8, 1985·European Journal of Pharmacology·G A KopiaB R Lucchesi

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