PMID: 6402856Jan 1, 1983Paper

Chronic viral hepatitis in thalassemic liver disease. A long-term study in patients with acute hepatitis with nontransfusion-dependent thalassemia minor

Vox Sanguinis
G PastoreO Schiraldi

Abstract

To evaluate the effective role of hepatitis viruses in thalassemic (Th) liver disease, we carried out a long-term study in 42 subjects with nontransfusion-dependent Th minor hospitalized for an episode of acute viral hepatitis. 10 patients had serologic evidence of hepatitis A, 23 of hepatitis B and 9 of hepatitis non-A, non-B. In the follow-up chronic hepatitis was detected histologically in 5/23 patients with hepatitis B and 5/9 with hepatitis non-A, non-B. All hepatitis A patients recovered completely. The prevalence in 7 out of 10 patients with chronic hepatitis of piecemeal necrosis and of inflammatory changes over hepatic siderosis and fibrosis evidenced a determinant role of chronic viral infection in the development of liver damage in these patients. Thus, heterozygous nontransfusion-dependent Th patients seem to have a high risk of developing a chronic inflammatory liver disease especially after an episode of non-A, non-B hepatitis. Therefore, in our geographical area, chronic hepatitis of viral origin should be taken into account, among other pathogenetic factors, in many cases of cryptogenic thalassemic liver disease.

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Citations

Aug 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·M L Van Dis, R P Langlais
Dec 1, 1984·Archives of Disease in Childhood·G A MoroniG Masera
Oct 1, 1992·The British Journal of Dermatology·K E McKenna, J F Dawson
Apr 8, 2020·The Journal of Antimicrobial Chemotherapy·Lindley A Barbee, Matthew R Golden

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