Chronically infected wild boar can transmit genotype 3 hepatitis E virus to domestic pigs

Veterinary Microbiology
Josephine SchlosserMartin Eiden

Abstract

Hepatitis E virus (HEV) causes acute hepatitis E in humans in developing countries, but sporadic and autochthonous cases do also occur in industrialized nations. In Europe, food-borne zoonotic transmission of genotype 3 (gt3) has been associated with the consumption of raw and undercooked products from domestic pig and wild boar. As shown recently, naturally acquired HEV gt3 replicates efficiently in experimentally infected wild boar and is transmissible from a wild boar to domestic pigs. Generally, following an acute infection swine suffer from a transient febrile illness and viremia in connection with fecal virus shedding. However, little is known about sub-acute or chronic HEV infections in swine, and how and where HEV survives the immune response. In this paper, we describe the incidental finding of a chronic HEVgt3 infection in two naturally infected European wild boar which were raised and housed at FLI over years. The wild boar displayed fecal HEV RNA excretion and viremia over nearly the whole observation period of more than five months. The animal had mounted a substantial antibody response, yet without initial clearance of the virus by the immune system. Further analysis indicated a subclinical course of HEV with no e...Continue Reading

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Citations

Mar 23, 2017·The Journal of Veterinary Medical Science·Hiroshi ShimodaKen Maeda
Aug 10, 2018·Transboundary and Emerging Diseases·Francini KlaumannJoaquim Segalés
Sep 13, 2018·Transboundary and Emerging Diseases·Luca De SabatoIlaria Di Bartolo
Aug 5, 2017·Medical Microbiology and Immunology·Anna Baumann-PopczykMałgorzata Sadkowska-Todys
May 28, 2019·Transboundary and Emerging Diseases·J Caballero-GómezA Rivero-Juarez
Dec 6, 2018·BMC Veterinary Research·Lisa DähnertMartin H Groschup
Sep 30, 2019·Virus Research·Ibrahim M SayedMohamed A El-Mokhtar

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