Chronically reduced IL-10 plasma levels are associated with hippocampal sclerosis in temporal lobe epilepsy patients

BMC Neurology
Pabitra BasnyatJ Peltola

Abstract

Increasing evidence supports the role of soluble inflammatory mediators in the pathogenesis of refractory temporal lobe epilepsy (TLE). Hippocampal sclerosis (HS) is a well-described pathohistological abnormality in TLE. The association of proinflammatory cytokines with epileptic disease profiles is well established; however, the potential significance of circulating interleukin 10 (IL-10), particularly in TLE-associated HS, is still poorly understood. Therefore, taking into consideration the neuroprotective and anticonvulsive effects of IL-10, we performed this study to examine the role of the plasma levels of IL-10 in patients with TLE with HS (TLE + HS), TLE without HS (TLE-HS) and with other types of epilepsy. This study included 270 patients with refractory epilepsy who were classified into four groups: i) 34 patients with TLE + HS, ii) 105 patients with TLE-HS, iii) 95 patients with extra-TLE (XLE) and iv) 36 patients with idiopathic generalized epilepsy (IGE). The plasma IL-10 levels were quantified using a commercially available enzyme-linked immunosorbent assay (ELISA). IL-10 levels were significantly lower in TLE + HS than in TLE-HS (p = 0.013). In a subgroup of TLE-HS patients who had seizures 1 month before sampling...Continue Reading

References

Mar 13, 2002·Seizure : the Journal of the British Epilepsy Association·J PeltolaT Keränen
Jan 29, 2003·Neurology·A T BergS S Spencer
Sep 26, 2003·The New England Journal of Medicine·Bernard S Chang, Daniel H Lowenstein
Dec 31, 2003·Journal of Neuroimmunology·Samantha S SoldanRhonda R Voskuhl
May 31, 2008·Journal of Neuroinflammation·Jing-Ji JinKen-Ichiro Fukuchi
Feb 16, 2010·Nature Reviews. Immunology·Margarida Saraiva, Anne O'Garra
Oct 12, 2011·Experimental Neurology·Annamaria VezzaniQuentin J Pittman
Oct 19, 2011·Biomarkers in Medicine·Annamaria Vezzani, Alon Friedman
Jan 5, 2012·Frontiers in Neuroendocrinology·Michael A GalicQuentin J Pittman
Mar 28, 2013·Mediators of Inflammation·Giulio KleinerGiorgio Zauli
Sep 4, 2013·Journal of Neuroimmunology·Suvi LiimatainenPeltola Jukka
Apr 26, 2014·Neuropathology and Applied Neurobiology·Maria Thom
Oct 1, 2015·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Marta GazalRicardo A da Silva
Sep 7, 2016·Acta Neurologica Scandinavica·F GaoY-J Li
Nov 25, 2016·Journal of Neuroinflammation·Diogo Lobo-SilvaMargarida Saraiva
Oct 11, 2017·The International Journal of Neuroscience·F Irsel TezerSerap Saygi
Dec 24, 2017·Journal of Neuroimmunology·Tiina AlapirttiJukka Peltola
Feb 27, 2018·Handbook of Clinical Neurology·Chris CotsapasDavid Hafler
Dec 14, 2018·Frontiers in Cellular Neuroscience·Amanda R Burmeister, Ian Marriott
Jul 2, 2019·JAMA Neurology·Marian GalovicMatthias J Koepp
Jul 3, 2019·Nature Reviews. Neurology·Annamaria VezzaniTeresa Ravizza

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Citations

May 8, 2021·BioMed Research International·Mengke LiangZhi Geng
May 27, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mehtap Kocatürk, Adnan Kirmit

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad
GraphPad Prism
Stata

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