Chronicles of a switch hunt: gcm genes in development

Trends in Genetics : TIG
M Wegner, D Riethmacher

Abstract

Co-conservation of sequence and function is an important principle during evolution. As a consequence, sequence-related genes often have similar functions in evolutionarily distant species. Enter the 'glial cells missing' (gcm) genes. They code for a small family of novel transcription factors that share DNA-binding properties and domain structure. However, no evolutionarily conserved function is apparent as yet. The prototypical gcm from Drosophila dominates nervous system development as a fate switch and master regulator of gliogenesis, whereas mammalian gcm genes have roles in placental morphogenesis and development of the parathyroid gland. Apparently, structure and function sometimes can go separate ways.

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Feb 6, 2004·Journal of Molecular Biology·Said HashemolhosseiniMichael Wegner
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui FuCharles D Stiles
Apr 17, 2014·Transgenic Research·Ziqiang YuanMichael A Levine
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Jun 15, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elena MarchioriIsabella Merante Boschin

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