Chrono-proteomics of human saliva: variations of the salivary proteome during human development

Journal of Proteome Research
Irene MessanaMassimo Castagnola

Abstract

An important contribution to the variability of any proteome is given by the time dimension that should be carefully considered to define physiological modifications. To this purpose, whole saliva proteome was investigated in a wide age range. Whole saliva was collected from 17 preterm newborns with a postconceptional age at birth of 178-217 days. In these subjects sample collection was performed serially starting immediately after birth and within about 1 year follow-up, gathering a total of 111 specimens. Furthermore, whole saliva was collected from 182 subjects aged between 0 and 17 years and from 23 adults aged between 27 and 57 years. The naturally occurring intact salivary proteome of the 316 samples was analyzed by low- and high-resolution HPLC-ESI-MS platforms. Proteins peculiar of the adults appeared in saliva with different time courses during human development. Acidic proline-rich proteins encoded by PRH2 locus and glycosylated basic proline-rich proteins encoded by PRB3 locus appeared following 180 days of postconceptional age, followed at 7 months (±2 weeks) by histatin 1, statherin, and P-B peptide. The other histatins and acidic proline-rich proteins encoded by PRH1 locus appeared in whole saliva of babies from 1...Continue Reading

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Citations

Oct 21, 2016·Clinical Oral Investigations·Thiago S CarvalhoAdrian Lussi
Mar 19, 2016·Journal of Separation Science·Barbara ManconiIrene Messana
Dec 13, 2017·Oral Diseases·P TorresV A Torres
Jan 13, 2018·PloS One·Sheila M F TorresXiong Wang
Aug 9, 2016·Expert Review of Proteomics·Gavino FaaMassimo Castagnola
May 6, 2017·Frontiers in Public Health·Mona Hassaneen, Jill L Maron
Jan 1, 2020·Journal of Biological Research·Katerina R Katsani, Dimitra Sakellari
Mar 13, 2020·Metabolomics : Official Journal of the Metabolomic Society·Eric NeyraudCarole Tournier
Aug 6, 2021·Journal of Separation Science·Mozhgan BoroumandMassimo Castagnola
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Eduardo J PatriarcaGabriella Minchiotti

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