PMID: 8588361Jan 1, 1995Paper

Chronobiology and chronopharmacology of cardiovascular diseases

Wiener medizinische Wochenschrift
B Lemmer

Abstract

Physiological functions as well as pathophysiological events--angina pectoris, myocardial infarction, sudden cardiac death--display pronounced circadian rhythms. Clinical studies also give evidence for a circadian phase dependency in the pharmacokinetics of cardio-vascular active drugs. Thus, a circadian phase dependency in the dose-response relationship of drugs has to be taken into account.

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