PMID: 7546828Jan 1, 1995Paper

Chronobiology. Implications for cancer chemotherapy

Acta Oncologica
G A Bjarnason

Abstract

Experimental studies have documented that both the toxicity and the antitumor activity of many cancer drugs are time dependent. Early clinical trials have confirmed this observation for several drugs. The basic concepts of chronobiology and its application to pharmacology are reviewed. As an example, clinical trials of circadian fluoropyrimidine delivery are reviewed. Other clinical results are presented in table form. The mechanisms pertinent to the circadian time dependence of fluoropyrimidines are discussed.

References

Feb 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E R BurnsT H Tsai
Oct 1, 1976·Molecular and Cellular Endocrinology·A HughesP W Jungblut
Sep 1, 1991·The Journal of Urology·F H DexeusR A Newman
Aug 7, 1991·Journal of the National Cancer Institute·R SmaalandO D Laerum
Nov 1, 1991·British Journal of Clinical Pharmacology·B Lemmer, G Nold
Aug 1, 1991·Gastroenterology·K N BuchiN H Rubin
Aug 1, 1990·Journal of Immunogenetics·C G Gahmberg
Mar 7, 1990·Journal of the National Cancer Institute·R von Roemeling, W J Hrushesky
Sep 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W J HrusheskyJ T Rabatin
Apr 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F LéviG Mathé
Nov 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R von Roemeling, W J Hrushesky
Jul 1, 1989·Physiological Reviews·J H Meijer, W J Rietveld
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·B A RobinsonJ R Sharman
Jul 25, 1985·The New England Journal of Medicine·M TuchmanB L Mirkin
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·R H BeckerM Treudler
Oct 1, 1988·Clinical Otolaryngology and Allied Sciences·P M Stell
Jan 1, 1988·Annual Review of Neuroscience·J C Hall, M Rosbash
Nov 1, 1988·European Journal of Cancer & Clinical Oncology·W T BellamyR T Dorr
Sep 2, 1988·Science·M R Ralph, M Menaker
Mar 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W J HrusheskyE Farley
Apr 5, 1985·Science·W J Hrushesky
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Sep 1, 1966·Journal of the National Cancer Institute·M Garcia-Sainz, F Halberg
Apr 15, 1980·Archives of Biochemistry and Biophysics·J Seifert
Aug 25, 1983·The New England Journal of Medicine·M C Moore-EdeG S Richardson
Sep 1, 1983·The New England Journal of Medicine·M C Moore-EdeG S Richardson

❮ Previous
Next ❯

Citations

Jul 5, 2005·Journal of Palliative Medicine·José Ferraz GonçalvesMaria Rosa Morais
Jan 1, 1997·Annual Review of Medicine·R Y Moore
May 1, 1997·European Journal of Haematology·J F AbrahamsenO D Laerum
Oct 8, 2020·Clinical Pharmacology and Therapeutics·James C WaltonRandy J Nelson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
J A Gonçalves
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P Hohenberger
© 2021 Meta ULC. All rights reserved