PMID: 20126992Feb 4, 2010Paper

Chronologic aging decreases tumor angiogenesis and metastasis in a mouse model of head and neck cancer

International Journal of Oncology
Bojana Bojovic, David L Crowe

Abstract

The incidence of malignant tumors increases with age. This may be due to the duration of carcinogenesis or age related changes providing a favorable environment for tumor formation. Aging is associated with molecular, cellular and physiological events that influence carcinogenesis and cancer growth. Physiologic cell proliferation, differentiation, and aging can result in cell death. However, under the influence of exogenous or endogenous factors cells can undergo pathologic dedifferentiation, immortalization, and neoplastic clone formation. The effects of age have been recognized in both animal and human malignancies. These processes can result in cellular senescence as a barrier to tumorigenesis. Inducing senescence is an important outcome for the successful treatment of cancers particularly those resistant to apoptosis. Senescence is associated with polyploidy in several human cell lines. Polyploid cells are dangerous in that they can undergo aberrant mitoses giving rise to unstable progeny. Polyploid cells have been shown to escape senescence and divide. We examined the effects of aging on squamous cell carcinoma formation in a mouse model. Chronologically aged mice experience shorter tumor latency periods than wild-type ani...Continue Reading

Citations

Jan 7, 2016·The Clinical Neuropsychologist·Geoffrey Davies, Adina Piovesana
Nov 26, 2014·Journal of Evaluation in Clinical Practice·Luis Salvador-CarullaJoachim Sturmberg
Jan 20, 2012·Journal of Neuropsychology·John R CrawfordAbigail M Batty
Oct 2, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Xiao-Li Tian, Yang Li
Oct 25, 2011·Neurobiology of Aging·Nivetha MurugesanJoel S Pachter
Feb 13, 2018·American Journal of Community Psychology·Andrew RasmussenSonia Roubeni
Jul 20, 2021·Frontiers in Cardiovascular Medicine·Gabriel Silva Marques BorgesSylvain Richard

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