PMID: 9444356Jan 28, 1998Paper

Chronological and immunohistochemical observations of cerebellar dysplasia and vermis defect in the hereditary cerebellar vermis defect (CVD) rat

Acta Neuropathologica
Mitsuru KuwamuraS Sakuma

Abstract

Hereditary cerebellar vermis defect (CVD) rats, a new neurological mutant, developed both cerebellar vermis defect and cerebellar dysplasia. Developmental alterations in the cerebellum of the CVD rats were studied chronologically and immunohistochemically. The earliest architectural abnormality was a maldevelopment of the inferior cerebellar peduncle from embryonic day 17 (E17), leading to an indistinct separation between the cerebellum and the pons. From E19, the CVD rats lacked vermis development and, therefore, the cerebellar hemispheres were fused. After birth, Purkinje cells and external granule cells (EGCs) penetrated into the pontine tissue, but retained their normal position until postnatal day 10. Cerebellar lamination began to be disturbed due to abnormal perivascular aggregations of the EGCs, resulting in convoluted and occasionally perivascular lamination. There were no Bergmann glia in the heterotopic cerebellum of the pons, and abnormally arranged Bergmann glia were observed in the mildly disorganized cerebellar hemispheres. Immunohistochemistry for calbindin revealed that abnormal orientation of the Purkinje cells might be related to the perivascular EGCs. Parvalbumin-immunopositive microneurons were seen only in...Continue Reading

Citations

Mar 11, 2004·Brain Research. Molecular Brain Research·Takashi KuramotoTadao Serikawa
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Doyeun Kim, Susan L Ackerman
Nov 20, 2012·Brain Structure & Function·Roy V SillitoeRichard Hawkes
Mar 3, 2004·Experimental Animals·Mitsuru KuwamuraTadao Serikawa
Oct 21, 2005·Journal of Neuroradiology. Journal De Neuroradiologie·G Soto-AresJ P Pruvo
Jul 10, 2004·Journal de radiologie·G Soto AresJ-P Pruvo

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