PMID: 11315094Apr 21, 2001Paper

Chronologically-specific metastatic targeting of human pancreatic tumors in orthotopic models

Clinical & Experimental Metastasis
M BouvetR M Hoffman

Abstract

Pancreatic cancer is a highly metastatic disease that responds poorly to currently-available treatment. In order to better visualize and understand the chronology and specificity of metastatic targeting of pancreatic cancer, two human pancreatic cancer cell lines, expressing green fluorescent protein (GFP), were studied in orthotopic models. MIA-PaCa2-GFP and BxPC-3-GFP tumor fragments were transplanted by surgical orthotopic implantation (SOI) to the nude mouse pancreas for fluorescence visualization of the chronology of pancreatic tumor growth and metastatic targeting. BxPC-3-GFP tumors developed rapidly in the pancreas and spread regionally to the spleen and retroperitoneum as early as six weeks. Distant metastases in BxPC-3-GFP were rare. In contrast, MIA-PaCa-2-GFP grew more slowly in the pancreas but rapidly metastasized to distant sites including liver and portal lymph nodes. Regional metastases in MIA-PaCa-2-GFP were rare. These studies demonstrate that pancreatic cancers have highly specific and individual 'seed-soil' interactions governing the chronology and sites of metastatic targeting.

Citations

Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·M ZhaoR M Hoffman
Nov 24, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J H HankeL V Ronco
Aug 28, 2007·International Journal of Cancer. Journal International Du Cancer·Yasushi ShintaniKeith R Johnson
May 14, 2016·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Kiyoshi HigashiTaro Tachibana
Oct 23, 2019·Frontiers in Oncology·Weina YuYi Zhang
May 11, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Elliot L ServaisPrasad S Adusumilli
Nov 2, 2012·Cancer Metastasis Reviews·Wanglong Qiu, Gloria H Su
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Meng YangRobert M Hoffman
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tengfei LiuKaitai Yao

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