Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth

ELife
Avinash Pujala, Minoru Koyama

Abstract

The emergence of new and increasingly sophisticated behaviors after birth is accompanied by dramatic increase of newly established synaptic connections in the nervous system. Little is known, however, of how nascent connections are organized to support such new behaviors alongside existing ones. To understand this, in the larval zebrafish we examined the development of spinal pathways from hindbrain V2a neurons and the role of these pathways in the development of locomotion. We found that new projections are continually layered laterally to existing neuropil, and give rise to distinct pathways that function in parallel to existing pathways. Across these chronologically layered pathways, the connectivity patterns and biophysical properties vary systematically to support a behavioral repertoire with a wide range of kinematics and dynamics. Such layering of new parallel circuits equipped with systematically changing properties may be central to the postnatal diversification and increasing sophistication of an animal's behavioral repertoire.

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Citations

Apr 5, 2019·ELife·Claire Wyart, Vatsala Thirumalai
May 24, 2019·Nature Communications·Yukiko Kimura, Shin-Ichi Higashijima
Feb 13, 2021·Neuron·Laurence D PictonAbdeljabbar El Manira
Nov 2, 2019·Current Opinion in Physiology·Michael Jay, David L McLean
Aug 8, 2021·International Journal of Molecular Sciences·Dylan Deska-Gauthier, Ying Zhang
Jan 11, 2022·PLoS Computational Biology·Gautam ReddyClaire Wyart

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Methods Mentioned

BETA
transgenic
dissection
light scattering

Software Mentioned

Image J
ScanImage
Zebrafish Brain Browser ( ZBB )
MATLAB
MATLAB script
nlme
Advanced Normalization Tools
Fiji
Imaris
R

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