PMID: 42527Jan 1, 1979

Chronology of the extrapyramidal effects of neuroleptics, and the nigrostriatal dopaminergic system

M PetitP Lesieur


Authors after analysis of the data in literature describe the chronologic appearance of the extrapyramidal effects of neuroleptics. In order to restore a neurophysiological coherence to dissimilar or even contradictory clinical emergences this sequence is analysed in function of the actual data, relative to the mechanism and to the modalities of adaptation of the dopaminergic synapse of the nigro striatal system.

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