Chronometric readout from a memory trace: gamma-frequency field stimulation recruits timed recurrent activity in the rat CA3 network

The Journal of Physiology
Shigeyoshi FujisawaYuji Ikegaya

Abstract

Synchronous population activity is prevalent in neurones of the central nervous system and experimentally captured as oscillatory electric fields, the frequency of which can represent the state of the neural circuit, e.g. theta (approximately 5 Hz) and gamma (approximately 40 Hz). Such field oscillations, however, are not merely a result of coherent neuronal activity. They may also play active roles in information processing in the brain. In this study, we observed that, in cultured hippocampal slices, CA3 pyramidal cells responded to single-pulse stimuli with monosynaptic and polysynaptic potentials and firing spikes which occurred after variable latencies. The variability of the spike latencies was greatly reduced in the presence of weak electric field oscillations, especially the oscillation in the gamma-band frequency range, that per se induced only small fluctuations in the subthreshold membrane potential, and this effect was inhibited by blockade of NMDA receptor activity. Furthermore, the latency of the firing spikes changed if the stimulus was applied at a different phase of the imposed gamma oscillations. These results may suggest that the background field oscillations serve as an extracellular time reference and assur...Continue Reading

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Citations

Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ryan T CanoltyJose M Carmena
May 27, 2008·Schizophrenia Bulletin·Gunvant K Thaker
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide ReatoLucas C Parra
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simal OzenGyörgy Buzsáki
Jun 30, 2007·The Journal of Physiology·Jacqueline K DeansJohn G R Jefferys
Jan 17, 2012·Neurobiology of Disease·John A SaundersSteve J Siegel
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Sep 30, 2014·Current Opinion in Neurobiology·Costas A Anastassiou, Christof Koch
Jul 14, 2010·Neuron·Flavio Fröhlich, David A McCormick
Apr 24, 2020·PLoS Computational Biology·Caglar Cakan, Klaus Obermayer
Oct 1, 2020·Neuroscience of Consciousness·Johnjoe McFadden
Mar 4, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·K-E LeeA V Goltsev
Dec 11, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M A LopesJ F F Mendes

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