Chronopharmacokinetic studies of pranoprofen and procainamide.

Journal of Clinical Pharmacology
A FujimuraA Ebihara

Abstract

There is increasing evidence demonstrating that plasma drug concentrations are affected by their time of administration. In the current study, the chronopharmacokinetic profiles of an antipyretic agent, pranoprofen, and an antiarrhythmic agent, procainamide, were examined. In the first study, 75 mg of pranoprofen was given orally in seven healthy subjects at 10:00 (morning trial) or 22:00 (evening trial). In the second study, 500 mg of procainamide was given orally in eight subjects with premature ventricular contractions at 10:00 or 22:00. Blood samples for plasma drug concentrations were taken for a 10-hour (pranoprofen study) or a 24-hour (procainamide study) post-drug period. In the first (pranoprofen) study, the mean time to maximum concentration was significantly shorter, and the mean maximum plasma concentration as well as absorption rate constant had a tendency to be greater after the morning than after the evening trial. The mean area under the plasma concentration-time curve, elimination half-life or oral clearance of the morning and evening dosages did not differ. In the second (procainamide) study, no significant difference was observed in any pharmacokinetic parameter concerning procainamide or its active metabolit...Continue Reading

References

Mar 1, 1978·Clinical Pharmacokinetics·E Karlsson
Jun 1, 1989·Journal of Clinical Pharmacology·A FujimuraA Ebihara
Jan 1, 1988·European Journal of Clinical Pharmacology·B Langner, B Lemmer
Mar 31, 1986·Life Sciences·A Fujimura, A Ebihara
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Citations

Jan 1, 1993·Life Sciences·B Bruguerolle, B Lemmer
Sep 17, 2013·Journal of Pharmaceutical and Biomedical Analysis·Tetsuya NemotoKeizo Sato
Mar 13, 2017·Cell Biology and Toxicology·Akira NakajimaTsuyoshi Yokoi

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