PMID: 9180363Jan 1, 1997Paper

Chronopharmacological study of KE-SI-TO in mice

Life Sciences
N OgawaS Higuchi

Abstract

Influence of dosing time on pharmacological effects and toxicity of KE-SI-TO (KST), analgesic and antipyretic drug, was investigated in ICR male mice under LD (12:12) cycle. Significant circadian rhythms were demonstrated for analgesic and hypothermal effects of KST (1 g/kg, i.p.) with higher values in the dark and lower ones in the light (p<0.01, respectively). The rhythmic patterns of KST-induced analgesia and hypothermia resembled overall the rhythms occuring in the nondrugged state. Injection of KST resulted in a parallel increasing in latency to hot plate and a parallel decreasing in rectal temperature. KST (6 g/kg, i.p.)-induced toxicity also showed a significant circadian rhythm with the highest mortality at 1700 and the lowest one at 0500 (p<0.05). The principles and concepts of biological rhythm should be included in the consideration of the actions of KST.

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Citations

Jan 1, 1997·Life Sciences·S OhdoS Higuchi
Jun 17, 1998·Life Sciences·S OhdoS Higuchi
Jan 4, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shigehiro Ohdo
Sep 16, 2006·Biochemical Pharmacology·Hiroo NakagawaShigehiro Ohdo

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