Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks
Correlation between blood pressure (BP) and target organ damage, vascular risk and long-term patient prognosis is greater for measurements derived from around-the-clock ambulatory BP monitoring than in-clinic daytime ones. Numerous studies consistently substantiate the asleep BP mean is both an independent and a much better predictor of cardiovascular disease (CVD) risk than either the awake or 24 h means. Sleep-time hypertension is much more prevalent than suspected, not only in patients with sleep disorders, but also among those who are elderly or have type 2 diabetes, chronic kidney disease or resistant hypertension. Hence, cost-effective adequate control of sleep-time BP is of marked clinical relevance. Ingestion time, according to circadian rhythms, of hypertension medications of six different classes and their combinations significantly affects BP control, particularly sleep-time BP, and adverse effects. For example, because the high-amplitude circadian rhythm of the renin-angiotensin-aldosterone system activates during nighttime sleep, bedtime vs. morning ingestion of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers better reduces the asleep BP mean, with additional benefit, independent of medic...Continue Reading
Associated Clinical Trials
Chronopharmacology of captopril plus hydrochlorothiazide in hypertension: morning versus evening dosing
Circadian characteristics of urinary epinephrine and norepinephrine from healthy young women in Japan and U.S.A
Influence of paternal (252) Cf neutron exposure on abnormal sperm, embryonal lethality, and liver tumorigenesis in the F(1) offspring of mice
Temporal (circadian) and functional relationship between atrial natriuretic peptides and blood pressure
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators
Comparison of effects of controlled onset extended release verapamil at bedtime and nifedipine gastrointestinal therapeutic system on arising on early morning blood pressure, heart rate, and the heart rate-blood pressure product
Renal response to the angiotensin II receptor subtype 1 antagonist irbesartan versus enalapril in hypertensive patients
Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative Group
Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
Relationship between physical activity and blood pressure in dipper and non-dipper hypertensive patients
Modeling the circadian variability of ambulatorily monitored blood pressure by multiple-component analysis
Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study
Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial
Administration time-dependent effects of valsartan on ambulatory blood pressure in hypertensive subjects
Prevalence, treatment, and control of hypertension in chronic hemodialysis patients in the United States
Effects of telmisartan 80 mg and valsartan 160 mg on ambulatory blood pressure in patients with essential hypertension
Administration-time-dependent effects of doxazosin GITS on ambulatory blood pressure of hypertensive subjects
Ambulatory blood pressure and 10-year risk of cardiovascular and noncardiovascular mortality: the Ohasama study
Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study
Effects of time of day of treatment on ambulatory blood pressure pattern of patients with resistant hypertension
Captopril administered at night restores the diurnal blood pressure rhythm in adequately controlled, nondipping hypertensives
Decrease in urinary albumin excretion associated with the normalization of nocturnal blood pressure in hypertensive subjects
Administration time-dependent effects of valsartan on ambulatory blood pressure in elderly hypertensive subjects
Effects of selective angiotensin II and beta1-receptor blockade on renal haemodynamics and sodium handling during orthostatic stress in healthy individuals
Association of impaired diurnal blood pressure variation with a subsequent decline in glomerular filtration rate
Predictors of all-cause mortality in clinical ambulatory monitoring: unique aspects of blood pressure during sleep
Relationship between diurnal blood pressure variation and diurnal blood glucose levels in type 2 diabetic patients
Dose- and administration time-dependent effects of nifedipine gits on ambulatory blood pressure in hypertensive subjects
Comparison of the efficacy of morning versus evening administration of telmisartan in essential hypertension
Chronotherapy of hypertension: administration-time-dependent effects of treatment on the circadian pattern of blood pressure
Chronotherapy improves blood pressure control and reverts the nondipper pattern in patients with resistant hypertension
Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: Rationale and design of the Hygia Project
Seven-day human biological rhythms: An expedition in search of their origin, synchronization, functional advantage, adaptive value and clinical relevance
The effects of missed doses of amlodipine and losartan on blood pressure in older hypertensive patients
Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension
Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients
Hypertension: New perspective on its definition and clinical management by bedtime therapy substantially reduces cardiovascular disease risk
Effects of melatonin on mechanisms involved in hypertension using human umbilical vein endothelial cells
Race and sex differences in asleep blood pressure: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Innovative lipid-based carriers containing cationic derivatives of polyisoprenoid alcohols augment the antihypertensive effectiveness of candesartan in spontaneously hypertensive rats
Valsartan chronotherapy reverts the non-dipper pattern and improves blood pressure control through mediation of circadian rhythms of the renin-angiotensin system in spontaneous hypertension rats
The Association Between Selected Molecular Biomarkers and Ambulatory Blood Pressure Patterns in African Chronic Kidney Disease and Hypertensive Patients Compared With Normotensive Controls: Protocol for a Longitudinal Study
Improved reduction of cardiovascular risk by bedtime ingestion of ARB and ACEI medication class therapies.
Total Atherosclerosis Burden of Baroreceptor-Resident Arteries Independently Predicts Blood Pressure Dipping in Patients With Ischemic Stroke.
Effect of 2 different anesthesia methods on stress response in neurosurgical patients with hypertension or normal: A prospective clinical trial
Perspectives on the relevance of the circadian time structure to workplace threshold limit values and employee biological monitoring
Ingestion-time - relative to circadian rhythms - differences in the pharmacokinetics and pharmacodynamics of hypertension medications.
Asleep blood pressure: significant prognostic marker of vascular risk and therapeutic target for prevention
Association of insulin resistance with polymorphic variants of Clock and Bmal1 genes: A case-control study
Effect of Morning vs. Evening Turmeric Consumption on Urine Oxidative Stress Biomarkers in Obese, Middle-Aged Adults: A Feasibility Study
Risk of incident chronic kidney disease is better reduced by bedtime than upon-awakening ingestion of hypertension medications
Pathophysiological mechanisms of mineralocorticoid receptor-dependent cardiovascular and chronic kidney disease
Genetic risk factors influence nighttime blood pressure and related cardiovascular complications in patients with coronary heart disease
Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial.
Treatment patterns and adherence to antihypertensive combination therapies in Japan using a claims database.
Translating research evidence into clinical practice: a reminder of important clinical lessons in management of resistant hypertension through a case study in general practice.
Ingestion-time differences in the pharmacodynamics of hypertension medications: Systematic review of human chronopharmacology trials.
Extent of asleep blood pressure reduction by hypertension medications is ingestion-time dependent: Systematic review and meta-analysis of published human trials.
Comparison of the antihypertensive efficacy of morning and bedtime dosing on reducing morning blood pressure surge: A protocol for systemic review and meta-analysis.
Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects
The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models.
Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension.
Antihypertensive Agents: Mechanisms of Action
Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.
CV Disorders & Type 2 Diabetes
This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.
Biomarkers for Cardiovascular Risk Assessment
Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.
Cardiovascular Diseases: Risk Factors
Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.
Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.
Biomarkers for Type 2 Diabetes
Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.
Cardiovascular Disease Pathophysiology
Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.
Biomarkers for Diabetes
This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.
Cardiovascular Disorder in Diabetes
Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.