Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Ramón C HermidaFrancesco Portaluppi

Abstract

Correlation between blood pressure (BP) and target organ damage, vascular risk and long-term patient prognosis is greater for measurements derived from around-the-clock ambulatory BP monitoring than in-clinic daytime ones. Numerous studies consistently substantiate the asleep BP mean is both an independent and a much better predictor of cardiovascular disease (CVD) risk than either the awake or 24 h means. Sleep-time hypertension is much more prevalent than suspected, not only in patients with sleep disorders, but also among those who are elderly or have type 2 diabetes, chronic kidney disease or resistant hypertension. Hence, cost-effective adequate control of sleep-time BP is of marked clinical relevance. Ingestion time, according to circadian rhythms, of hypertension medications of six different classes and their combinations significantly affects BP control, particularly sleep-time BP, and adverse effects. For example, because the high-amplitude circadian rhythm of the renin-angiotensin-aldosterone system activates during nighttime sleep, bedtime vs. morning ingestion of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers better reduces the asleep BP mean, with additional benefit, independent of medic...Continue Reading

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Citations

Jun 7, 2016·Journal of Pineal Research·Fedor SimkoRussel J Reiter
Jun 24, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sante D PierdomenicoEttore Porreca
Dec 3, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naro OhashiHideo Yasuda
Feb 7, 2017·Biology·Davide Gnocchi, Giovannella Bruscalupi
Jan 20, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Peter W de LeeuwAbraham A Kroon
Sep 25, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Yan ChenKai-Hang Yiu
Apr 11, 2018·Cephalalgia : an International Journal of Headache·Mads BarloeseRigmor Jensen
Mar 7, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naro OhashiHideo Yasuda
Oct 20, 2017·Journal of Toxicology and Environmental Health. Part a·Guangfang ShaoJian Tong
Feb 1, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuharu TabaraUNKNOWN and the Nagahama study group
Feb 7, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shigehiro KatayamaMasashi Issiki
Feb 15, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Olga GawryśElżbieta Kompanowska-Jezierska
Apr 30, 2017·Journal of the American Society of Nephrology : JASN·Ramón C HermidaJosé R Fernández
Apr 7, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Davide GnocchiAntonio Mazzocca
Apr 17, 2020·European Heart Journal·Ramón C HermidaManuel Domínguez-Sardiña
Jun 17, 2020·Expert Opinion on Pharmacotherapy·Ramón C HermidaJosé R Fernández
Sep 18, 2020·Expert Opinion on Drug Metabolism & Toxicology·Ramón C HermidaJosé R Fernández
Jun 10, 2017·Current Hypertension Reports·Andrew Y HwangSteven M Smith
Aug 19, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sébastien FoulquierThomas Unger
Aug 15, 2018·European Heart Journal·Ramón C HermidaUNKNOWN Hygia Project Investigators
Oct 16, 2019·Clinical and Experimental Hypertension : CHE·Gui-Yang LiHui Chen
Jun 12, 2020·International Journal of Environmental Research and Public Health·Cynthia Blanton, Barbara Gordon
Mar 14, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ramón C HermidaJosé R Fernández
May 24, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kei AsayamaMasahiro Kikuya
Dec 14, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira Nishiyama
Feb 11, 2020·Expert Opinion on Pharmacotherapy·Tatsuya MaruhashiYukihito Higashi
Oct 6, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Marcin WirtweinWojciech Sobiczewski
Oct 24, 2019·European Heart Journal·Ramón C HermidaUNKNOWN Hygia Project Investigators
Jan 9, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Reham H SolimanDavid M Pollock
Nov 18, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takayuki IshidaTakuya Tsuchihashi
Aug 11, 2020·Current Cardiology Reports·Ramón C HermidaJosé R Fernández
Apr 23, 2020·Drug Discovery Today·Ana Cláudia Soares, Diogo A Fonseca
Feb 2, 2019·Autonomic Neuroscience : Basic & Clinical·Bryan K BeckerDavid M Pollock
Jun 26, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Nicola Di TraniAlessandro Grattoni

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