Chronotolerance study of the antiepileptic drug valproic acid in mice.

Journal of Circadian Rhythms
Wafa Ben-CherifNaceur A Boughattas

Abstract

Valproic acid (VPA) is an antiepileptic drug widely used for the treatment of absence seizures and generalized tonic-clonic seizures. The present work aims to study whether VPA-induced toxicity varies according to the dosing-time in the 24 hour-scale. The influence of dosing-time on tolerance to VPA was investigated in 120 male Swiss mice synchronized under a light-dark cycle (12:12). The mean VPA lethal dose was first determined to be 850 ± 0.2 mg/kg, i.p.. Such a dose was administered by i.p. route to a total of 90 mice divided in six circadian stages [1, 5, 9, 13, 17 and 21 Hours After Light Onset (HALO)] (15 mice/circadian time); 30 mice were used as control (5 mice / circadian time). The surviving treated mice exhibited a significant circadian variation in rectal temperature and body weight loss (p < 0.001). The least rectal temperature change and body weight loss occurred when VPA was injected at 9 HALO. Drug dosing at 9 HALO resulted in -9 % weight loss whereas drug dosing at 17 HALO was -15 % (Ø = 20.3 HALO ± 1.1 h, p ≤ 0.0001). Lethal toxicity also varied according to circadian dosing-time (χ2 = 42.1, p < 0.0001). The highest (60 %) and the lowest (6.67 %) survival rates were observed at 9 HALO and 17 HALO respectively...Continue Reading

References

Sep 1, 1992·Epilepsy Research·N Y Walton, D M Treiman
Jan 1, 1992·Annual Review of Pharmacology and Toxicology·A E Reinberg
Oct 1, 1985·European Journal of Cancer & Clinical Oncology·F LeviG Mathe
Feb 5, 1993·Neuroscience Letters·R Y Moore, J C Speh
Jun 1, 1993·The American Review of Respiratory Disease·M H Smolensky, G E D'Alonzo
Oct 6, 1995·European Journal of Pharmacology·S OhdoT Sugiyama
Feb 1, 1996·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B Lemmer
Mar 1, 1996·Japanese Journal of Pharmacology·S OhdoT Sugiyama
Jan 1, 1997·Life Sciences·J P Bolaños, J M Medina
Jul 13, 2000·Neurology·S B ZachariahJ T Stewart
Sep 21, 2000·Epilepsy Research·M Quigg
Oct 24, 2001·Epilepsy Research·S Arroyo, A de la Morena
Jul 11, 2003·Pathologie-biologie·Fabrice Kwiatkowski, Francis Lévi
Dec 19, 2003·Chronobiology International·Achraf KhedhaierNaceur A Boughattas
May 8, 2004·Chronobiology International·Yvan TouitouLudger Rensing
Aug 23, 2007·Emergency Medicine Journal : EMJ·H K R Thanacoody
Jul 1, 2008·Epilepsy & Behavior : E&B·Wytske A Hofstra, Al W de Weerd
Sep 19, 2009·Trends in Pharmacological Sciences·Natalia N NalivaevaAnthony J Turner
Sep 30, 2009·Epilepsy & Behavior : E&B·Milena K PavlovaEdward B Bromfield
Jan 12, 2010·Journal of Affective Disorders·Hui Hua ChangRu Band Lu
Oct 26, 2010·Chronobiology International·Francesco PortaluppiYvan Touitou
Nov 16, 2010·Seizure : the Journal of the British Epilepsy Association·Martin J Brodie
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Tobias LoddenkemperSanjeev V Kothare
Jun 21, 2011·Journal of Circadian Rhythms·Mamane SaniMossadok Ben-Attia
Jan 1, 2007·Biological Rhythm Research·Roberto RefinettiFranz Halberg

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Citations

Mar 5, 2013·Current Neurology and Neuroscience Reports·Sriram RamgopalTobias Loddenkemper
May 28, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wafa Ben-CherifNaceur A Boughattas
Feb 15, 2020·British Journal of Pharmacology·Joana BickerAna Fortuna
Oct 28, 2018·Lancet Neurology·Sofia KhanSofia H Eriksson

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Methods Mentioned

BETA
pharmacotherapy
sedation

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