Abstract
Whether phosphodiesterase inhibitors increase the heart rate in patients with bradyarrhythmias is not known. We attempted to determine whether the oral phosphodiesterase inhibitor cilostazol exhibits beneficial chronotropic effects in patients with symptomatic bradyarrhythmias. Twenty patients comprising eight with bradycardic atrial fibrillation, eight with sick sinus syndrome, and four with Wenckebach-type atrioventricular block, whose 24-h total heart-beat count was < or =70,000 beats and whose maximal RR interval was > or =2.5 s, were enrolled. Holter recordings (24-h) were made before and 2 weeks after oral daily administration of 200 mg of cilostazol. Cilostazol increased the 24-h total heart-beat count from 77,429 +/- 11,168 to 107,981 +/- 13,536 (95% confidence interval, 24,605-36,497; p < 0.0001), the minimal heart rate from 33 +/- 9 47 +/- 13 beats/min (95% confidence interval, 9-19 beats/min; p < 0.0001), and the maximal RR interval from 3,149 +/- 1,018 to 2,087 +/- 601 ms (95% confidence interval, -1,517 to -608 ms; p = 0.0001). Only two patients had headaches as adverse effects. In conclusion, cilostazol had a beneficial positive chronotropic effect in patients with bradyarrhythmias, especially with bradycardic atr...Continue Reading
References
Nov 1, 1979·Circulation Research·A A AlousiC J Opalka
Jul 1, 1979·Circulation·P SteeleR Vogel
Oct 1, 1992·Chest·A LaupacisW Feinberg
Dec 1, 1992·Chest·G J Merli
Nov 1, 1991·American Heart Journal·P AlboniG E Antonioli
Apr 15, 1990·The American Journal of Cardiology·P AlboniG E Antonioli
Jan 1, 1987·Chest·T B ConradsonG Persson
Jan 3, 1989·The American Journal of Cardiology·G V Naccarelli, R A Goldstein
May 1, 1987·Chest·P J Barnes
Jan 1, 1987·Chest·M L Aitken, T R Martin
Mar 1, 1986·The American Journal of Cardiology·R A GoldsteinG V Naccarelli
Nov 1, 1983·Journal of Cardiovascular Pharmacology·R W PiwonkaA E Farah
Dec 1, 1983·The American Journal of Cardiology·D G BendittM M Scheinman
Sep 1, 1984·The American Journal of Cardiology·G V NaccarelliR A Goldstein
Apr 1, 1983·Chemical & Pharmaceutical Bulletin·T NishiK Nakagawa
Dec 1, 1981·Chest·A K PatelJ H Thomsen
Dec 1, 1981·Chest·J Pearle
Apr 1, 1993·Journal of the American College of Cardiology·D SaitoS Haraoka
Mar 15, 1996·Circulation·E N PrystowskyD G Wyse
Sep 15, 1996·Circulation·S SunayamaH Yamaguchi
Oct 8, 1996·The American Journal of Medicine·M Shalowitz, A H Heaton
Citations
Jan 1, 2008·Case Reports in Gastroenterology·David S MorrisMark D Sawyer
Apr 2, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiro YasutakeHirokazu Hayakawa
Dec 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Sang Hak LeeChong-Yun Rhim
Sep 17, 2011·Internal Medicine·Asami NimuraNaoyuki Hasebe
Apr 18, 2014·Internal Medicine·Yuji AokiNobuaki Watanabe
Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Natnicha KanlopNipon Chattipakorn
Jan 29, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bence PatocskaiCharles Antzelevitch
Aug 6, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tamás SzélCharles Antzelevitch
Nov 13, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kohei IguchiWataru Shimizu
Apr 10, 2003·Chest·Koji Kodama-TakahashiTakeru Iwata
Feb 28, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Sep 10, 2014·Journal of Atherosclerosis and Thrombosis·Beom-June KwonKi-Bae Seung
Apr 21, 2011·Echocardiography·Hisao YoshikawaKaoru Sugi
Apr 3, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Naomasa MakitaHiroyuki Tsutsui
Dec 6, 2005·Resuscitation·UNKNOWN International Liaison Committee on Resuscitation
Sep 29, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Naomasa MakitaHiroyuki Tsutsui
Apr 15, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles Antzelevitch, Gan-Xin Yan
Jul 18, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles AntzelevitchArthur A M Wilde
Oct 21, 2016·Journal of Arrhythmia·Charles AntzelevitchArthur A M Wilde
May 2, 2017·The Journal of Veterinary Medical Science·Nobuyuki Kanno, Tomohiro Suzuki
Oct 2, 2004·The Journal of International Medical Research·I MoriyaT Kanda
Nov 28, 2013·Perfusion·E AlizadeA M Esen
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·S ToyonagaT Tsuji
Dec 20, 2017·Journal of Arrhythmia·Megumi KisanukiKoichi Akashi
Jan 19, 2002·Hypertension·Karl-Heinz HofbauerPeter Sandner
Sep 6, 2019·International Heart Journal·Tomoki UchikawaHiroyuki Tsutsui
Jan 5, 2011·Journal of Cardiovascular Medicine·Natnicha KanlopNipon Chattipakorn
Jan 23, 2019·Frontiers in Pharmacology·Cho-Kai WuChia-Hsuin Chang
Nov 2, 2019·JFMS Open Reports·Naoki IwasaHitoshi Kitagawa
Apr 22, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Charles AntzelevitchArthur A M Wilde
Oct 6, 2020·Annual Review of Pharmacology and Toxicology·Pietro MesircaMatteo E Mangoni
Aug 12, 2004·British Journal of Anaesthesia·T IshiyamaT Kumazawa
Oct 22, 2021·Journal of Clinical Pharmacology·Antonis A ManolisAntonis S Manolis