Chronotropic response to exercise testing is associated with carotid atherosclerosis in healthy middle-aged men

European Heart Journal
Sae Young JaeWon Hah Park

Abstract

Chronotropic incompetence, an attenuated heart rate (HR) response to exercise, is an independent predictor of cardiovascular mortality, but it is not known whether chronotropic incompetence is related to carotid atherosclerosis. The association between chronotropic incompetence and carotid atherosclerosis in 8567 (age 47.6+/-8.8 years) healthy men was examined. Chronotropic incompetence was defined as the failure to achieve 85% of the age-predicted maximal HR (APMHR), <80% HR reserve (HRR), and chronotropic response index (CRI). Carotid atherosclerosis was defined, using B-mode ultrasonography, as stenosis >25% and/or intima-media thickness (IMT) of >1.2 mm. In multivariable adjusted logistic regression models, the subjects who achieved less than 85% of APMHR exhibited an odds ratio (OR) of 1.72 [95% confidence intervals (CI): 1.32-2.22] for carotid atherosclerosis. Subjects with <80% of HRR were 1.45 (95% CI: 1.14-1.84) times more likely to have carotid atherosclerosis after multivariate adjustment. Also, the OR of carotid atherosclerosis across quartiles of CRI (highest to lowest) was 1.51 (95% CI: 1.10-2.09) after multivariate adjustment. These results suggest that the chronotropic response to exercise is associated with car...Continue Reading

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Citations

Jan 26, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Tatsuya KawasakiHiroki Sugihara
Feb 21, 2007·Clinical Physiology and Functional Imaging·Espen F BakkeEinar Stranden
Mar 23, 2006·European Heart Journal·Johan De SutterIvan Elegeert
Nov 20, 2013·Journal of Hypertension·Sae Young JaeJeong Bae Park
Feb 3, 2021·Journal of Sport and Health Science·Wouter M A FranssenDominique Hansen
Dec 22, 2020·The American Journal of Cardiology·Sae Young JaeJari A Laukkanen

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