Chrysin alleviates allergic inflammation and airway remodeling in a murine model of chronic asthma

International Immunopharmacology
Jing YaoGan-Zhu Feng

Abstract

Asthma is a chronic airway inflammatory disorder and progresses mainly due to airway remodeling. Chrysin, a natural flavonoid, has been reported to possess multiple biologic activities, including anti-inflammation, anti-oxidation and anti-proliferation. The present study aimed to investigate whether chrysin could relieve allergic airway inflammation and remodeling in a murine model of chronic asthma and the mechanism involved. The female BALB/c mice sensitized and challenged with ovalbumin (OVA) successfully developed airway hyperresponsiveness (AHR), inflammation and remodeling. The experimental data showed that chrysin could alleviate OVA-induced AHR. Chrysin could also reduce OVA-induced increases in the number of inflammatory cells, especially eosinophils, interleukin (IL) -4, and IL-13 in bronchoalveolar lavage fluid (BALF) and total IgE in serum. The decreased interferon-γ (IFN-γ) level in BALF was also upregulated by chrysin. In addition, inflammatory cell infiltration, goblet cell hyperplasia and the expression of α-smooth muscle actin (α-SMA) around bronchioles were suppressed by chrysin. Furthermore, the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) could be decreased by chrysin, which ...Continue Reading

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Jul 1, 2016·Drug Discoveries & Therapeutics·Tanongsak Sassa-DeepaengSiriporn Okonogi
Jul 18, 2018·International Journal of Molecular Medicine·Xiaohua ZhuYing Zhong
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Jun 15, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Majid ZeinaliHossein Hosseinzadeh
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marjan TalebiSaeed Samarghandian

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