Chrysin attenuates allergic airway inflammation by modulating the transcription factors T-bet and GATA-3 in mice

Molecular Medicine Reports
Qiang DuMei Su

Abstract

Chrysin, a flavonoid obtained from various natural sources, has been reported to possess anti-inflammatory, antitumor, antioxidant and anti-allergic activities. However, its anti-inflammatory and immunoregulatory activities in asthma animal models are poorly understood. In the present study, we examined the effects of chrysin on airway inflammation and the possible mechanisms through which it acts in a murine model of allergic asthma. BALB/c mice sensitized and challenged to ovalbumin (OVA) were administered intragastrically with chrysin at a dose of 50 mg/kg daily. Chrysin significantly suppressed OVA-induced airway hyperresponsiveness (AHR) to acetylcholine chloride (Ach). Chrysin administration significantly inhibited the total inflammatory cell and eosinophil counts in bronchoalveolar lavage fluid (BALF) and total immunoglobulin E (IgE) levels in serum. Histological examination of lung tissue demonstrated that chrysin significantly attenuated allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells in the airway. In addition, chrysin triggered a switch of the immune response to allergens towards a T-helper type 1 (Th1) profile by modulating the transcription factors T-bet and GATA-3 in allergic mice....Continue Reading

Citations

Jun 12, 2013·Nutrients·Toshio Tanaka, Ryo Takahashi
Apr 8, 2014·Biochemical Pharmacology·Xiujing FengPingping Shen
Jan 19, 2016·International Immunopharmacology·Jing YaoGanzhu Feng
Nov 26, 2015·The Journal of Nutritional Biochemistry·Mar Abril-GilMargarida Castell
Jan 18, 2015·Toxicology Letters·Eshvendar Reddy KasalaChandana C Barua
May 13, 2021·Critical Reviews in Food Science and Nutrition·Venkata Sita Rama Raju AllamKamal Dua

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