Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Iman H El KhashabA S Attia

Abstract

Global cerebral ischemia is a leading cause of mortality worldwide. Several biomechanisms play a role in the pathology of cerebral ischemia reperfusion damage, such as oxidative stress, inflammation, apoptosis and excitotoxicity. Chrysin, a natural flavonoid with many important biological activities, was investigated in the present study for its possible neuroprotective properties in a rat model of global ischemia reperfusion. Male Wistar rats were allocated into three groups: sham-operated, ischemia/reperfusion, and chrysin (30 mg/kg) groups. All animals were subjected to ischemia for 15 min followed by reperfusion for 60 min, except for the sham-operated group. Rats were decapitated, then both hippocampi were rapidly excised to evaluate several biomarkers that reflect ischemic injury. The obtained results showed that pre-treatment with chrysin attenuated ischemia-induced oxidative stress by: (i) restoring the glutathione level; and (ii) depressing the levels/activities of thiobarbituric acid reactive substances, the hippocampal NADPH, as well as the xanthine oxidase. Exposure to chrysin also suppressed the inflammation accompanying the ischemia/reperfusion (I/R) damage, through increasing the interleukin-10 level, while decre...Continue Reading

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Citations

Feb 11, 2020·Neurochemical Research·Ekrem Darendelioglu
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Aug 18, 2020·Drug Design, Development and Therapy·Taiyang LiaoPeimin Wang
Sep 20, 2020·Nature Communications·Xiaozhou LiDongshan Zhang
Apr 2, 2021·Frontiers in Cell and Developmental Biology·Yiming DengZhongrong Miao
Apr 6, 2021·Journal of Cardiovascular Pharmacology·Li XingyueYang Yongjian

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