Chrysin-loaded bovine serum albumin particles as bioactive nanosupplements.

Food & Function
Joana B FerradoLiliana G Santiago

Abstract

Development of nanosupplements based on bioactive compound encapsulation and their incorporation into diet constitutes a field that is growing exponentially. Among flavonoids, chrysin (Chrys) shows high antitumor activity but its poor water solubility limits its applications. Bovine serum albumin nanoparticles (BSAnp) with sizes in the range of 13-28 nm were previously prepared by applying a heat-induced self-assembly method, and they were able to load Chrys. Hence, the aim of this study is to provide information about elaboration of Chrys nanosupplements considering the incidence of the freeze-drying process of Chrys-loaded and unloaded BSAnp systems on aqueous redispersibility and on the retention of their physicochemical properties as examined by DSC, turbidity and DLS measurements. In general, the physicochemical properties of Chrys-loaded BSAnp were retained after the freeze-drying process. The cytotoxic activity of the reconstituted powders was assayed on MCF-7 and MDA-MB-231 cell lines (as models of cancer cell lines) by using the MTT assay. Furthermore, the mechanism of cell death was researched by Annexin V-FITC flow cytometry. The apoptosis-mediated cytotoxicity was higher for Chrys-loaded BSAnp than for the BSAnp sys...Continue Reading

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Sep 29, 2018·Colloids and Surfaces. B, Biointerfaces·Joana B FerradoLiliana G Santiago

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Citations

Oct 1, 2020·Biomolecules·Ebrahim Rahmani MoghadamAlan Prem Kumar
May 2, 2021·Colloids and Surfaces. B, Biointerfaces·Joana B FerradoLiliana G Santiago

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Methods Mentioned

BETA
thermal treatment
differential scanning calorimetry
dynamic light scattering
flow cytometry

Software Mentioned

StatGraphics Plus
FlowJo
Chrys

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