Chrysin suppress immune responses and protects from experimental autoimmune encephalomyelitis in mice

Journal of Neuroimmunology
Lucian Del FabbroCristiano Ricardo Jesse

Abstract

We investigated the effects of chrysin in the experimental autoimmune encephomyelitis (EAE), a multiple sclerosis (MS) animal model. EAE was induced using myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide in C57BL/6 mice. Chrysin reduced weight loss, attenuated clinical signs and blunted the EAE-induced increase in histone deacetylase (HDCA) activity, glycogen synthase kinase-3β (GSK-3β) levels and pro-inflammatory cytokine levels as well as in the EAE-induced decrease in histone acetyltransferases 3 and 4 (HAT3, HAT4). Altogether, results demonstrate beneficial effects and potential targets of chrysin in EAE.

References

Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·J DeLucaR A Engel
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A E JuedesN H Ruddle
May 12, 2004·Neuron·Marianna YanikeWendy A Suzuki
May 19, 2005·Bipolar Disorders·W Jonathan RyvesRobin Sb Williams
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yutaka KomiyamaYoichiro Iwakura
Feb 19, 2008·Nature Medicine·Ingunn M StromnesJoan M Goverman
Jul 19, 2008·Journal of Neurochemistry·Huiping DingGail V W Johnson
Oct 8, 2009·Annals of Neurology·Hania KebirAlexandre Prat
Mar 23, 2010·Journal of Neuroimmunology·David Henrique RodriguesAntônio Lúcio Teixeira
Apr 22, 2010·CNS & Neurological Disorders Drug Targets·S Schmalbach, S Petri
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Farah H Bardai, Santosh R D'Mello
Feb 5, 2011·Nutrition and Cancer·Ramamurthi Vidya PriyadarsiniSiddavaram Nagini
Mar 30, 2011·Annals of Neurology·Ranjan DuttaBruce D Trapp
Sep 24, 2011·Frontiers in Molecular Neuroscience·Eléonore Beurel
Mar 2, 2013·Current Pharmaceutical Design·Lutz GarbesBrunhilde Wirth
Apr 23, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eléonore BeurelRichard S Jope
Feb 12, 2014·Magnetic Resonance Imaging·Katherine A KoenigMicheal D Phillips
Mar 22, 2014·Neuromolecular Medicine·Cem Ismail KüçükaliErdem Tüzün
Nov 5, 2014·Neuromolecular Medicine·Rongwei ZhangYanqing Tang
Dec 31, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Sorabh Sharma, Rajeev Taliyan
Feb 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Guohua WangJun Chen
Feb 9, 2017·Current Alzheimer Research·Vincenzina NicoliaAndrea Fuso
Jul 2, 2017·Biologicals : Journal of the International Association of Biological Standardization·Cristiano RossatoFernando S Silva
Sep 20, 2017·European Journal of Medicinal Chemistry·Carmela SpagnuoloGian Luigi Russo
May 12, 2014·Toxicology Reports·Micheli Stéfani ZarzeckiMarina Prigol

❮ Previous
Next ❯

Citations

Jan 16, 2020·Current Pharmaceutical Design·Joana BickerAmílcar Falcão
Oct 1, 2020·Biomolecules·Ebrahim Rahmani MoghadamAlan Prem Kumar
Oct 12, 2020·Neurochemical Research·Micheli Stéfani ZarzeckiCristiano Ricardo Jesse
Jul 3, 2021·Nutrients·Monika Stompor-GorącyMaciej Machaczka
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marjan TalebiSaeed Samarghandian
Dec 18, 2020·Chemical Research in Toxicology·Jianhui ChenGuixia Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.