Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

The Journal of Pharmacy and Pharmacology
Long XieXiaofang Li

Abstract

Chrysophanol is a natural anthraquinone, also known as chrysophanic acid and 1,8-dihydroxy-3-methyl-anthraquinone. It has been widely used in the food and pharmaceutical fields. This review is intended to provide a comprehensive overview of the pharmacology, toxicity and pharmacokinetic researches of chrysophanol. Information on chrysophanol was collected from the Internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library and Europe PM using a combination of keywords including 'pharmacology', 'toxicology' and 'pharmacokinetics'. The literature we collected included from January 2010 to June 2019. Chrysophanol has a wide spectrum of pharmacological effects, including anticancer, antioxidation, neuroprotection, antibacterial and antiviral, and regulating blood lipids. However, chrysophanol has obvious hepatotoxicity and nephrotoxicity, and pharmacokinetics indicate that the use of chrysophanol in combination with other drugs can reduce toxicity and enhance efficacy. Chrysophanol can be used in many diseases. Future research directions include how the concentration of chrysophanol affects pharmacological effects and toxicity; the mechanism of synergy between chrysophanol and other drugs.

References

Mar 1, 1983·Mutation Research·L TikkanenS Natori
Jul 10, 2007·Bioscience, Biotechnology, and Biochemistry·Zeng-hui TengQi-bing Mei
Nov 5, 2008·Biological & Pharmaceutical Bulletin·Myung Sun Lee, Cheon Bae Sohn
Sep 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Su-Jin KimJae-Young Um
Nov 23, 2010·Phytotherapy Research : PTR·Myung Sun LeeJi Yeon Kim
Aug 23, 2011·Journal of Ethnopharmacology·Chi-Sheng ShiaYu-Chi Hou
Jan 19, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui ZhangYanxia Han
Apr 10, 2012·Apoptosis : an International Journal on Programmed Cell Death·Yao YaoYu-Xin Li
Oct 19, 2013·Biomedical Chromatography : BMC·Wenjin WuYitao Wang
Dec 5, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yan WangDavid Chi-Cheong Wan
Jan 8, 2014·Archives of Pharmacal Research·Shu-Jen ChangCheng-Wen Lin
Dec 3, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Qinhua ChenPeng Li
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Paulo Henrique Muleta AndradeMaria de Fatima Cepa Matos
Jul 3, 2015·Biological & Pharmaceutical Bulletin·Liping MaSu Zeng
Apr 2, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuting CuiXuebo Liu
Oct 9, 2016·Journal of Ethnopharmacology·Edgar E Caamal-FuentesRosa E Moo-Puc
Feb 6, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Li KangJiangeng Huang
Apr 13, 2017·Toxicology Mechanisms and Methods·Chunyan ZhangChunhua Ma
May 6, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Peijin LiKun Hao
Jul 14, 2017·Immunopharmacology and Immunotoxicology·Unbin ChaeDong-Seok Lee
Oct 17, 2017·European Journal of Pharmacology·Yongmei ZhaoYumin Luo

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Citations

Dec 15, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Junjie YinXudong Wei
Jul 16, 2020·The Journal of Pharmacy and Pharmacology·Da-Bao ChenBiao Cai
Jul 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Po-Chih HsuHuey-Kang Sytwu
Jan 19, 2021·Journal of Ethnopharmacology·Wen ZhangBangjiang Fang
Dec 5, 2020·Oxidative Medicine and Cellular Longevity·Xueying LiuChuangpeng Shen
Jun 3, 2021·Marine Drugs·Giulia GrecoCarmela Fimognari
Oct 1, 2020·Pharmacology & Therapeutics·Tao TaoJohn H Zhang
Jul 3, 2021·Applied Biochemistry and Biotechnology·Kaushik Kumar BharadwajSiddhartha Pati
Oct 13, 2021·Biofouling·Débora de Souza Collares Maia Castelo-BrancoMarcos Fábio Gadelha Rocha

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