Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice

Neurochemical Research
Xu ChuQingxia Kong

Abstract

Patients with diabetes mellitus are easy to experience diabetic encephalopathy (DE) and other cognition dysfunction, whereas the neural alterations in developing this disease are unknown yet. Chrysophanol (CHR) is one of traditional Chinese medicine which was reported to show protective effects in cognition dysfunction and inflammatory in previously studies. In this current study, whether CHR protects learning and memory dysfunctions induced by diabetes disease or not and underlying mechanisms were studied. DE model was induced by streptozotocin (STZ, i.p.) in ICR mice. CHR was administrated 3 days after STZ treated mice which was confirmed with diabetes for consecutive 6 days. Learning and memory function was tested by Morris water maze after the CHR injection. The morphology of neuronal cells in hippocampus CA3 region was stained by HE-staining. ELISA and Western blot assay were used to determine the levels of pro-inflammation cytokines (IL-1β, IL-4, IL-6, TNF-α) in hippocampus. Here, we demonstrated that mice harboring diabetes mellitus induced by STZ exhibit high blood glucose, learning and memory deficits detected by Morris water maze behavior tests. Application with CHR right after developing diabetes disease rescues part...Continue Reading

References

Jun 1, 1990·The Journal of Comparative Neurology·M J West, H J Gundersen
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Apr 20, 2004·European Journal of Pharmacology·Anders A F SimaZhen Guo Li
May 19, 2004·Archives of Neurology·Zoe ArvanitakisDavid A Bennett
Apr 15, 2006·The Oncologist·Remco van HorssenAlexander M M Eggermont
Jan 22, 2008·Lancet Neurology·Geert Jan BiesselsChristopher M Ryan
Jan 31, 2008·Advances in Cardiology·Enrique Z FismanAlexander Tenenbaum
Nov 5, 2008·Biological & Pharmaceutical Bulletin·Myung Sun Lee, Cheon Bae Sohn
Sep 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Su-Jin KimJae-Young Um
Jun 12, 2012·Lancet·Rory J McCrimmonBrian M Frier
Dec 25, 2012·Expert Review of Cardiovascular Therapy·Tariq BhatThomas Costantino
Feb 26, 2014·The Journal of International Medical Research·Fatih SefilCumali Gokce
May 17, 2014·Metabolic Brain Disease·Aarti NagayachIshan Patro
Sep 7, 2014·Behavioural Brain Research·Daniel R ZamzowKathy R Magnusson
Jun 27, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Beiyun WangYuan Zhong
May 14, 2016·Brain Research·Wilma Helena OliveiraChristina Alves Peixoto
Mar 3, 2017·Nature Reviews. Neuroscience·Nelson RebolaChristophe Mulle
Mar 10, 2017·Expert Review of Clinical Pharmacology·Sherifa A Hamed
Apr 20, 2017·Frontiers in Molecular Neuroscience·Andrea Becerra-Calixto, Gloria P Cardona-Gómez
Apr 27, 2017·Annals of Pediatric Endocrinology & Metabolism·Seungah Lee, Dong Yun Lee
May 6, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Peijin LiKun Hao
May 10, 2017·Frontiers in Immunology·Hua SuChun Zhang
May 13, 2017·Journal of Clinical Medicine Research·Alaaeldin BashierFatheya Alawadi
Jul 14, 2017·Immunopharmacology and Immunotoxicology·Unbin ChaeDong-Seok Lee
Jul 22, 2017·Current Neuropharmacology·Marc Fakhoury
Nov 19, 2017·Journal of Neuroimmunology·Bing Pei, Jian Sun

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Citations

Nov 28, 2019·Phytotherapy Research : PTR·Aminu MohammedMurtala Bindawa Isah
Jul 16, 2020·The Journal of Pharmacy and Pharmacology·Da-Bao ChenBiao Cai
Aug 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mengshan HeHongling He
Mar 10, 2020·Acta Biochimica Et Biophysica Sinica·Xuhong FanJi Xiao
Aug 29, 2020·International Journal of Molecular Sciences·Hyun-Su Lee, Gil-Saeng Jeong
Aug 3, 2019·The Journal of Pharmacy and Pharmacology·Long XieXiaofang Li
Dec 11, 2019·Drug Development Research·Kavya JashKiran Kalia
Jun 22, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xun LiNaihong Chen
Jan 14, 2021·International Immunopharmacology·Shahab GhaderiKhodabakhsh Rashidi
Jul 12, 2019·Heliyon·Ahmad GhorbaniAzar Hosseini
Nov 26, 2020·Drug Design, Development and Therapy·Chuan GuoDehai Yin
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyun-Su Lee, Gil-Saeng Jeong

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Methods Mentioned

BETA
transgenic
ELISA
protein
electrophoresis
X-ray
light microscopy

Software Mentioned

Image J
StereoInvestigator

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